Results 211 to 220 of about 3,091,272 (307)

A data portrait-based approach to precision education for medical students in China. [PDF]

Medicine (Baltimore)
Yu S, Ju X, Ling C.
europepmc   +1 more source

Consistent Techno‐Economic and Environmental Assessment of Hydrogen Production via Electrolysis

Chemie Ingenieur Technik, EarlyView.
This study performs a techno‐economic and life‐cycle analysis of hydrogen production via electrolysis under five electricity supply scenarios, including flexible operation with a baseload. Results highlight trade‐offs between cost and carbon intensity, exhibiting economic and ecological inefficiency of grid supportive electrolysis in Germany.
Alexandra Göbel, Johanna Valasko Gassenheimer, Stephan Mohr, Tamara Hanstein, Florian Ausfelder   +4 more
wiley   +1 more source

Frequentist Identification of Effective Baskets via the Generalized Information Criteria in Oncology Phase 2 Trials. [PDF]

Stat Med
Tanaka S, Ohara R, Hattori S.
europepmc   +1 more source

Joint copula‐based beta regression with covariate‐dependent dispersion for malaria indicators

Canadian Journal of Statistics, EarlyView.
Abstract Malaria surveillance relies on multiple indicators that reflect different aspects of transmission and disease burden, yet these outcomes are often analyzed separately under constant‐variance assumptions. Such approaches may obscure residual dependence and heterogeneity in variability. Using Demographic and Health Survey data from Burkina Faso (
Guanjie Lyu, Cindy Feng
wiley   +1 more source

Gendered socioeconomic impacts of emerging infectious diseases: Insights from a mixed-methods study in Guinea. [PDF]

One Health
Maltais S, Beaulieu J, Hounmenou CG, Bangoura ST, Koniono GL, Bongono EF, Camara A, Masumu J, Touré A.   +8 more
europepmc   +1 more source

Model‐Informed Approaches for Pediatric Type 2 Diabetes Evidence Generation: Insights from a Model‐Based Longitudinal HbA1c Meta‐Analysis from EMA Marketing Authorization Applications

Clinical Pharmacology &Therapeutics, EarlyView.
Evidence generation for antihyperglycemic therapies in pediatric type 2 diabetes mellitus (T2DM) remains challenging, with most randomized trials failing to demonstrate statistically significant reductions in glycated hemoglobin (HbA1c), partly due to substantial between‐subject variability.
Pieter J. Colin, Efthymios Manolis, Jeroen V. Koomen   +2 more
wiley   +1 more source

A method for detecting small objects in remote sensing images based on feature enhancement and scale-adaptive optimization in complex scenarios. [PDF]

PLoS One
Wang X, Zou X, Sun M, Jia C, Xie Y, Zhang X.   +5 more
europepmc   +1 more source

The household burden of sleeping sickness: out-of-pocket costs for diagnosis and treatment. [PDF]

BMJ Glob Health
Snijders R, Fukinsia A, Nganzobo P, Miaka E, Hasker E, Mpanya A, Antillon M, Tediosi F.   +7 more
europepmc   +1 more source

Overview of Regulatory Guidelines Related to Methods and Models for Small Populations

Clinical Pharmacology &Therapeutics, EarlyView.
This paper provides an overview of approaches and related guidelines from the EMA, FDA, and ICH that are relevant for obtaining clinical evidence for small populations to support regulatory decision making. The approaches are grouped into three categories: (1) maximizing the attainable sample size, (2) adapting the trial design to deal with a small ...
Laurens Sluijterman, Letao Li, Kristin E. Karlsson, Vincent Damotte, Sarah Zohar, Kit Roes, Joanna IntHout   +6 more
wiley   +1 more source