Results 71 to 80 of about 53,085 (229)
OXCT1‐driven succinylation of PSMG3 stabilizes the proteasome to facilitate picornavirus replication
iMetaOmics, EarlyView.Upon entering the pig, foot‐and‐mouth disease virus (FMDV) regulates host glycolysis and the citrate cycle by modulating the expression of metabolic enzymes, resulting in changes in post‐translational modifications (PTMs) including succinylation, lactylation, crotonylation, acetylation, and phosphorylation.
Huisheng Liu +9 more
wiley +1 more source
Haematologica, 2012 Background Multiple myeloma, a malignancy of the antibody-secreting plasma cells, remains incurable by current therapy. However, the proteasome inhibitor bortezomib and other new drugs are revolutionizing its treatment.
Silvia C. W. Ling +11 more
doaj +1 more source
iNew Medicine, EarlyView.Using 18 global databases, this country‐level ecological study identified major positive and negative correlates of multiple myeloma prevalence and death rate, providing hypothesis‐generating evidence to inform future public health research and policy development.
Peng Xu +8 more
wiley +1 more source
Journal of Neuroinflammation, 2018 Background Bortezomib is a frequently used chemotherapeutic drug for the treatment of multiple myeloma and other nonsolid malignancies. Accumulating evidence has demonstrated that bortezomib-induced persistent pain serves as the most frequent reason for ...
Kun Chen +5 more
doaj +1 more source
A Case of Systemic Amyloidosis Diagnosed After Excision of a Cutaneous Tumour of the Buttocks
JEADV Clinical Practice, EarlyView.ABSTRACT A 72‐year‐old Japanese man was referred to our hospital with two tumours on the buttocks. Two solitary, 2.5 × 1.5 cm‐sized, dark brown, well‐demarcated elevated plaques were observed, one on each side of the gluteal cleft, and dermoscopic examination showed comedo‐like openings, multiple milia‐like cysts, and a cerebriform pattern with ...
Tomomichi Shimizu +9 more
wiley +1 more source
Muscle &Nerve, EarlyView.ABSTRACT Introduction/Aims Electrophysiologic features suggestive of demyelination have been reported in vasculitic neuropathy, complicating the diagnostic process, but their frequency is unknown. We aimed to determine the prevalence of demyelinating features, including fulfillment of European Academy of Neurology/Peripheral Nerve Society (EAN/PNS ...
Alexandra Maury +7 more
wiley +1 more source
Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma
Frontiers in Oncology, 2019 Multiple myeloma (MM) drug resistance highlights a need for alternative therapeutic strategies. In this study, we show that CASIN, a selective inhibitor of cell division cycle 42 (Cdc42) GTPase, inhibited proliferation and survival of melphalan ...
Phuong Nguyen +13 more
doaj +1 more source
Smart Molecules, EarlyView.The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou +4 more
wiley +1 more source
Extramedullary Plasmacytoma of Base of Tongue: A Systematic Review
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Objective Identifying extramedullary plasmacytoma originating from the base‐of‐tongue, in order to evaluate its prevalence, characteristics, management, and treatment within the broader spectrum of head and neck extramedullary plasmacytoma.
Ori Cohen Michael +6 more
wiley +1 more source
PLoS ONE, 2013 CK2 is a pivotal pro-survival protein kinase in multiple myeloma that may likely impinge on bortezomib-regulated cellular pathways. In the present study, we investigated CK2 expression in multiple myeloma and mantle cell lymphoma, two bortezomib ...
Sabrina Manni +16 more
doaj +1 more source