Results 51 to 60 of about 13,876,063 (349)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Impact of Boundary Conditions on Entrainment and Transport in Gravity Currents [PDF]

, 2006
Gravity currents have been studied numerically and experimentally both in the laboratory and in the ocean. The question of appropriate boundary conditions is still challenging for most complex flows.
Boñgolan-Walsh, Vena Pearl, Duan, Jinqiao, Fischer, Paul, Iliescu, Traian, Özgökmen, Tamay   +4 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Efficient Organic Carbon Burial by Bottom Currents in the Ocean: A Potential Role in Climate Modulation

Geophysical Research Letters
Bottom currents play a major role in deep‐sea sedimentation, but their significance in the burial of organic carbon is poorly quantified at a global scale.
Shaoru Yin, F. Javier Hernández‐Molina, Weijia Fan, Jiabiao Li   +3 more
doaj   +1 more source

Gravity current down a steeply inclined slope in a rotating fluid [PDF]

Annales Geophysicae, 1997
The sinking of dense water down a steep continental slope is studied using laboratory experiments, theoretical analysis and numerical simulation.
G. I. Shapiro, A. G. Zatsepin
doaj   +1 more source

Charming the Higgs

, 2013
We show that current Higgs data permit a significantly enhanced Higgs coupling to charm pairs, comparable to the Higgs to bottom pairs coupling in the Standard Model, without resorting to additional new physics sources in Higgs production.
Delaunay, Cédric, Golling, Tobias, Perez, Gilad, Soreq, Yotam   +3 more
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Characterization and mechanism of resuspension events induced by internal tides at the toe of Shenhu canyon

Applied Ocean Research
Understanding sediment resuspension in deep-sea (primarily deeper than 1000 m) environments is critical for environmental impact assessments and engineering planning.
Cong Hu, Hui Wang, Chunsheng Ji, Xuezhi Feng, Zhaoyang Tian, Yonggang Jia   +5 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source