Results 51 to 60 of about 3,555,401 (304)
Impact of Boundary Conditions on Entrainment and Transport in Gravity Currents [PDF]
, 2006 Gravity currents have been studied numerically and experimentally both in the laboratory and in the ocean. The question of appropriate boundary conditions is still challenging for most complex flows.
Boñgolan-Walsh, Vena Pearl +4 more
core +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Applied Ocean ResearchUnderstanding sediment resuspension in deep-sea (primarily deeper than 1000 m) environments is critical for environmental impact assessments and engineering planning.
Cong Hu +5 more
doaj +1 more source
RRS James Clark Ross, December 18, 2002–January 4, 2003. ACCLAIM: Sea level measurements in the Drake Passage [PDF]
, 2004 ACCLAIM Bottom Pressure Recorders have been used for making measurements of the Antarctic Circumpolar Current (ACC) since 1988, initially in the Scotia Sea and then later the Drake Passage between the Falkland Islands and the Antarctic peninsula. Some of
Mack, S.
core
Lateral and Bottom Forces on Longshore Currents
Coastal Engineering 1976, 1976 A two-component electromagnetic flowmeter has been used on a natural beach of slope 0.01 to measure mean longshore currents and the horizontal fluctuating velocities in the frequency range 0-1 Hz. The measurements extend up to 120 m offshore and span about one third of a wide surf-zone.
openaire +1 more source
Near-Bottom Velocities in Waves with a Current
Coastal Engineering 1978, 1978 Bakker (1974) developed a mathematical model concerning the sand concentration and velocity distribution in an oscillatory turbulent flow, with or without resultant current. The flow is assumed to be uniform in horizontal direction. The present paper reports on an experimental verification of this theory.
W.T. Bakker, Th. Van Doorn
openaire +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Geophysical Research LettersDeep‐sea rare earth elements and yttrium (REY)‐rich sediments have attracted considerable attention since their discovery in 2011. However, the environmental factors controlling REY enrichment remain poorly understood, largely because paleoceanographic ...
Xiangfeng He +8 more
doaj +1 more source
, 2011 A multilayer edge molecular electronics device (MEMED), which utilize the two metal electrodes of a metal-insulator-metal tunnel junction as the two electrical leads to molecular channels, can overcome the long standing fabrication challenges for ...
Tyagi, Pawan
core +1 more source