Results 51 to 60 of about 27,676 (260)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Object-Based Mapping of Coral Reef Habitats Using Planet Dove Satellites

open access: yesRemote Sensing, 2019
High spatial resolution benthic habitat information is essential for coral reef protection and coastal environmental management. Satellite-based shallow benthic composition mapping offers a more efficient approach than traditional field measurements ...
Jiwei Li   +3 more
doaj   +1 more source

Reflection of Pulses from the Ocean Bottom [PDF]

open access: yesThe Journal of the Acoustical Society of America, 1961
The macroscopic physical properties of the ocean bottom have received considerable attention in recent years. Two important points of view which serve as motivation for such studies are acoustical and geological in nature. Experimental records of explosion pulses were obtained before and after reflection from the relatively smooth and level Hatteras ...
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Autonomous Coral Reef Survey in Support of Remote Sensing

open access: yesFrontiers in Marine Science, 2017
An autonomous surface vehicle instrumented with optical and acoustical sensors was deployed in Kane'ohe Bay, HI, U.S.A., to provide high-resolution, in situ observations of coral reef reflectance with minimal human presence.
Steven G. Ackleson   +4 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Satellite monitoring of coral reef responses to the 2022 volcanic ash deposition of the Hunga Tonga–Hunga Ha‘apai

open access: yesEnvironmental Research Letters
Volcanic ash deposition can influence coral reef ecosystems, yet its impacts remain poorly quantified due to the rarity and limited field observations. Here, we combined Sentinel-2 imagery with a shallow-water radiative transfer model to retrieve bottom ...
Yunhan Ma   +5 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Hyperspectral Estimation of Layer-Specific Leaf Nitrogen Content in Potato Canopy by Integrating Fractional-Order Derivatives and Three-Band Spectral Indices

open access: yesPlants
To address the insufficient characterization of vertical heterogeneity in potato canopy leaf nitrogen content (LNC), this study developed a layer-specific LNC estimation framework based on canopy hyperspectral reflectance, fractional-order derivative ...
Ming Jin   +9 more
doaj   +1 more source

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