Results 61 to 70 of about 27,676 (260)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Remotely sensing coral bleaching in the Red Sea

Remote Sensing in Ecology and Conservation
Coral bleaching, often triggered by oceanic warming, has a devastating impact on coral reef systems, resulting in substantial alterations to biodiversity and ecosystem services.
Elamurugu Alias Gokul, Dionysios E. Raitsos, Robert J. W. Brewin, Susana Carvalho, Khaled Asfahani, Ibrahim Hoteit   +5 more
doaj   +1 more source

Recovery of Optical Transport Coefficients Using Diffusion Approximation in Bilayered Tissues: A Theoretical Analysis

Photonics
Time-domain (TD) diffuse reflectance can be modeled using diffusion theory (DT) to non-invasively estimate optical transport coefficients of biological media, which serve as markers of tissue physiology.
Suraj Rajasekhar, Karthik Vishwanath
doaj   +1 more source

Estimation of Nitrogen Vertical Distribution by Bi-Directional Canopy Reflectance in Winter Wheat

Sensors, 2014
Timely measurement of vertical foliage nitrogen distribution is critical for increasing crop yield and reducing environmental impact. In this study, a novel method with partial least square regression (PLSR) and vegetation indices was developed to ...
Wenjiang Huang, Qinying Yang, Ruiliang Pu, Shaoyuan Yang   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A sequential method for estimating the optical properties of two-layer agro-products from spatially-resolved diffuse reflectance: Simulation

Artificial Intelligence in Agriculture, 2019
A sequential method for estimating the optical properties of two-layer biological tissues with spatially-resolved diffuse reflectance was proposed and validated using Monte Carlo simulations.
Aichen Wang, Xinhua Wei
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Diffuse attenuation coefficient and bathymetry retrieval in shallow water environments by integrating satellite laser altimetry with optical remote sensing

International Journal of Applied Earth Observations and Geoinformation
Shallow water environmental information is crucial for the study of marine ecosystems and human activities. There have been numerous satellite remote sensing studies focused on this area. However, accurate information acquisition from remote sensing data
Changda Liu, Huan Xie, Qi Xu, Jie Li, Yuan Sun, Min Ji, Xiaohua Tong   +6 more
doaj   +1 more source