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Safety and Clinical Outcomes of an Equine-derived Heptavalent Botulinum Antitoxin Treatment for Confirmed or Suspected Botulism in the United States

Clinical Infectious Diseases, 2020
BACKGROUND Botulism is a rare, life-threatening paralytic illness. BAT® [Botulism Antitoxin Heptavalent (A,B,C,D,E,F,G)-(Equine)] is an equine-derived heptavalent botulinum antitoxin product indicated for the treatment of symptomatic botulism following ...
Jason S Richardson, Geraldine S Parrera
exaly   +2 more sources

Delivery of single-domain antibodies into neurons using a chimeric toxin–based platform is therapeutic in mouse models of botulism

Science Translational Medicine, 2021
A detoxified chimeric toxin–based platform delivers therapeutics into neurons and has therapeutic effects in mouse models of botulism. Nontoxic botulinum for drug delivery Botulism is a severe and potentially fatal disease characterized by muscle ...
Shin-Ichiro Miyashita   +4 more
semanticscholar   +1 more source

Epidemiological Analysis of Foodborne Botulism Outbreaks — China, 2004–2020

China CDC Weekly, 2022
Introduction Foodborne botulism is a rare, potentially fatal illness resulting from the ingestion of foods contaminated with preformed botulinum neurotoxin types A, B, E, or F, produced by Clostridium botulinum.
Hongqiu Li   +8 more
semanticscholar   +1 more source

Iatrogenic Botulism: A Case Treated With Botulinum Antitoxin

Clinical neuropharmacology, 2022
Objective Botulinum toxin type A is widely used for the treatment of spasticity, focal dystonia, hemifacial spasm, hyperhidrosis, strabismus, chronic migraine, and also cosmetic purposes. Therapeutic use is commonly effective and safe.
Ozge Gonul Oner   +3 more
semanticscholar   +1 more source

Infant botulism: an underestimated threat

Infectious Diseases, 2021
Infant botulism (IB) is defined as a potentially life-threatening neuroparalytic disorder affecting children younger than 12 months. It is caused by ingestion of food or dust contaminated by Clostridium botulinum spores, which germinate in the infant’s ...
Luca Antonucci   +4 more
semanticscholar   +1 more source

Efficacy of detection canines for avian botulism surveillance and mitigation

Conservation Science and Practice, 2021
Hawai'i's endangered waterbirds have experienced epizootics caused by ingestion of prey that accumulated a botulinum neurotoxin produced by the anaerobic bacterium Clostridium botulinum (avian botulism; Type C).
M. Reynolds   +5 more
semanticscholar   +1 more source

Infant Botulism

Southern Medical Journal, 1981
The work of Thompson et al1 presents findings in nine Utah patients with infant botulism. In contrast to several other authorities who failed to demonstrate Botulobacillas botulinus in infants of the same age without evidence of clinical disease, Thompson et al1 report a significant number of positive stool cultures in infants who showed no evidence of
R A, Broughton, J, Campbell, H D, Wilson
  +8 more sources

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