Results 51 to 60 of about 5,231 (285)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Adjoint Based Design Approach for Boundary Layer Ingestion Offset Intake
, 2009 The design of boundary layer ingestion offset intake is conducted by using a gradientbased optimization method. A large amount of boundary layer ingestion into flush-mounted intake on a configuration surface can cause total pressure loss and distortion ...
Lee, Byung Joon +3 more
core +1 more source
Examining the Benefits of Boundary Layer Ingestion on Powered Bodies
, 2023 57th 3AF International Conference on Applied Aerodynamics (AERO2023), Bordeaux, France, 29-31 March ...
Mutangara, N.E. +3 more
openaire +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Unsteady loss mechanisms in a boundary layer ingestion fan under inlet distortion
FlowBoundary layer ingestion (BLI) propulsion can improve aircraft aerodynamic efficiency, but also introduces inlet distortion that affects fan flow and stability.
Junyang Yu +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Techno-economic and environmental risk assessment of a turbo-electric distributed propulsion system on a blended wing body aircraft [PDF]
, 2014 Constant rise of air traffic has caused the environmental impacts of aviation to be the subject of an unprecedented scrutiny. Organisations all over the world are setting targets for emission reductions that represent the technological potential for ...
Giakoumakis, Eleftherios
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
, 2023 This database contains the datasets for the aeroacoustic experiments conducted at the University of Bristol regarding Boundary Layer Ingestion configurations A1 and A2 as part of the H2020 ENODISE project.
Falsi, Michele +4 more
core +1 more source