Results 41 to 50 of about 644,622 (267)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Remote SensingAccurately extracting long-term urban and rural settlement (URS) information is crucial for studying urbanization processes and their impacts on the ecological environment.
Xiaopeng Li +5 more
doaj +1 more source
Boundary conditions in supergravity on a manifold with boundary [PDF]
Journal of High Energy Physics, 2006 We explain why it is necessary to use boundary conditions in the proof of supersymmetry of a supergravity action on a manifold with boundary. Working in both boundary (``downstairs'') and orbifold (``upstairs'') pictures, we present a bulk-plus-boundary/brane action for the five-dimensional (on-shell) supergravity which is supersymmetric with the use ...
openaire +4 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Game without game: to Gilles Deleuze’s game concept
Семиотические исследованияThe article provides a critical analysis of the "ideal game" concept by Gilles Deleuze. The problematic type of Deleuze's judgments about the game leads to the fact that the game is understood by him as a logical subject devoid of the predicate.
Yuriy A. Razinov, Dmitriy A. Kechaev
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Atmospheric Science LettersNorth China experienced an extreme precipitation event from July 29 to August 1, 2023 (i.e., the “23.7” event) causing severe floods, significant infrastructure damage and multiple fatalities.
Xiaofan Li +6 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Breaking the Binary Oppositions of the Interior: A Momentary Permanence
Interiority, 2019 The previously static view of the interior is changing, as social, economic and cultural factors produce a new requirement for building flexibility and potentially forcing a change to the normal spatial paradigms.
Roderick Adams, Lucy Marlor
doaj +1 more source