Results 131 to 140 of about 648,510 (309)
Outflow Boundary Conditions for Turbine-Integrated Rotating Detonation Combustors
Applied SciencesThis study examines outflow boundary conditions (BCs) in computational fluid dynamics (CFD) simulations of a transition duct with and without guide vanes that converts supersonic flow exiting a rotating detonation combustor (RDC) to subsonic flow to ...
Tsung-Ming Hsieh +4 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The structure of a three-dimensional turbulent boundary layer
, 1993 The three-dimensional turbulent boundary layer is shown to have a self-consistent two-layer asymptotic structure in the limit of large Reynolds number.
Degani, AT, Smith, FT, Walker, JDA
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An ACA Accelerated isogeometric boundary element analysis of potential problems with non-uniform boundary conditions [PDF]
, 2017 This paper presents an Adaptive Cross Approximation (ACA) accelerated Isogeometric Boundary Element Method (IGBEM) using Non-Uniform Rational B-Splines (NURBS) as shape and interpolation functions. Provided that NURBS are used in CAD programs to describe
Campos, LS, Wrobel, LC, Albuquerque, EL
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Differential Equations Third Order Inhomogeneous Linear with Boundary Conditions [PDF]
Considering the importance of teaching linear differential equations, it can be said that every physical and technical phenomenon, which is expressed and modeled in mathematical sciences, is a differential equation.
Ghulam Hazrat, Aimal Rasa
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Eigenvalues of Sturm-Liouville problems with discontinuous boundary conditions
Electronic Journal of Differential Equations, 2017 For classical regular two-point self-adjoint Sturm-Liouville problems (SLP) the dependence of the eigenvalues on the boundary conditions is well understood because of some surprisingly recent results.
Aiping Wang, Anton Zettl
doaj