Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Integrable Boundary Flows and the g-function [PDF]
, 2012 This thesis explores renormalisation group flows in integrable quantum field theories with boundaries, as described by the g-function. The main focus is on the g-function in the staircase model, the renormalisation group flow of which passes close to the
WILBOURNE, RUTH,MARGARET +1 more
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Efficient generation of inflow conditions for large-eddy simulation of street-scale flows
, 2008 Using a numerical weather forecasting code to provide the dynamic largescale inlet boundary conditions for the computation of small-scale urban canopy flows requires a continuous specification of appropriate inlet turbulence.
Xie, Zheng-Tong, Castro, Ian P.
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Effective Surface and Boundary Condition for Heterogeneous Salt Media with Insoluble Material [PDF]
, 2013 Effective Surface and Boundary Condition for Heterogeneous Salt Media with Insoluble ...
Veran-Tissoires, Stéphanie +2 more
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Mean Curvature Flow with a Neumann Boundary Condition in Flat Spaces [PDF]
, 2012 In this thesis I study mean curvature flow in both Euclidean and Minkowski space with a Neumann boundary condition. In Minkowski space I show that for a convex timelike cone boundary condition, with compatible spacelike initial data, mean curvature flow
LAMBERT, BENJAMIN,STEPHEN
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Solution of the Fokker-Planck equation with boundary conditions by Feynman-Kac integration. [PDF]
In this paper, we apply the results about d and d-function perturbations in order to formulate within the Feynman-Kac integration the solution of the forward Fokker-Planck equation subject to Dirichlet or Neumann boundary conditions.
Decamps, Marc +2 more
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A numerical model study of the stratocumulus-topped marine boundary layer [PDF]
, 1999 A one-dimensional model with second order turbulence closure has been developed and used to investigate processes in the cloud-topped marine atmospheric boundary layer.
Kent, E.C.
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