Results 151 to 160 of about 406,966 (316)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Unsteadiness in shock-wave/boundary layer interactions [PDF]
, 2010 The need for better understanding of the low-frequency unsteadiness observed in shockwave/turbulent boundary layer interactions has been driving research in this area forseveral decades.
Touber, Emile
core
Weighted multiple model adaptive boundary control for a flexible manipulator. [PDF]
Sci Prog, 2020 Zhang W, Li Q, Zhang Y, Lu Z, Nian C.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A Model of the Control Problem of the Thermal Effect of a Laser Beam on a Two-Layer Biomaterial
MathematicsWe consider a two-layer biological object consisting of layers with different thermophysical characteristics and subjected to laser radiation. Using the method of separation of variables and methods of control theory for finite-dimensional systems, we ...
Vanya Barseghyan, Svetlana Solodusha
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
MathematicsTo address the problems of the traditional Supply–Demand Optimization (SDO) algorithm in wireless sensor network (WSN) node deployment—such as blind search direction, weak global exploration capability, coarse boundary handling, and insufficient ...
Bowei Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
VALUATION OF BOUNDARY-LINKED ASSETS [PDF]
This article studies the valuation of boundary-linked assets and their derivatives in continuous-time markets. Valuing boundary-linked assets requires the solution of a stochastic differential equation with boundary conditions, which, often, is not ...
Mercedes Esteban-Bravo +1 more
core