Results 131 to 140 of about 404,554 (315)
DNA hypermethylation/boundary control loss identified in retinoblastomas associated with genetic and epigenetic inactivation of the RB1 gene promoter. [PDF]
Epigenetics, 2021 Raizis AM +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
An ACA Accelerated isogeometric boundary element analysis of potential problems with non-uniform boundary conditions [PDF]
, 2017 This paper presents an Adaptive Cross Approximation (ACA) accelerated Isogeometric Boundary Element Method (IGBEM) using Non-Uniform Rational B-Splines (NURBS) as shape and interpolation functions. Provided that NURBS are used in CAD programs to describe
Campos, LS, Wrobel, LC, Albuquerque, EL
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
An improved turbulent boundary layer inflow condition, applied to the simulation of jets in cross-flow [PDF]
The jet acting perpendicular to a cross-flow boundary layer is a commonly studied complex turbulent flow. Our research was motivated by their potential application in separation delay devices, where jets can be used to produce streamwise vortices in a ...
Jewkes, James
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Experimental investigation of unsteadiness in transonic shock boundary layer interaction [PDF]
, 2010 Transonic shock wave/boundary layer interaction over a wall-mounted bump was investigated with specific focus on shock wave unsteadiness and identification of its source. A large separation bubble resulted of an interaction driven by a flow characterized
Raghunathan, Srinivasan +2 more
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Stabilization of ODE-Schrodinger cascaded systems subject to boundary control matched disturbance
Electronic Journal of Differential Equations, 2015 In this article, we consider the state feedback stabilization of ODE-Schrodinger cascaded systems with the external disturbance. We use the backstepping transformation to handle the unstable part of the ODE, then design a feedback control which is ...
Ya-Ping Guo, Jun-Jun Liu
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Optimal fluctuations and the control of chaos. [PDF]
, 2002 The energy-optimal migration of a chaotic oscillator from one attractor to another coexisting attractor is investigated via an analogy between the Hamiltonian theory of fluctuations and Hamiltonian formulation of the control problem.
Luchinsky, D. G. +4 more
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