The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Damping problem for the hyperbolic equation with mixed derivative
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2011 The boundary control problem for the hyperbolic equation with mixed derivative was considered in the rectangular region. The control functions were constructed in an explicit form.
Elena A Kozlova
doaj
On Attainability of Optimal Solutions for Linear Elliptic Equations with Unbounded Coefficients
Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Modelûvannâ, 2011 We study an optimal boundary control problem (OCP) associated to a linear elliptic equation —div (Vj/ + A(x)Vy) = f describing diffusion in a turbulent flow. The characteristic feature of this equation is the fact that, in applications, the stream matrix
P. I. Kogut, O. P. Kupenko
doaj +1 more source
Grain Boundary Control of Organic Semiconductors via Solvent Vapor Annealing for High-Sensitivity NO2 Detection. [PDF]
Sensors (Basel), 2021 Hou S, Zhuang X, Fan H, Yu J.
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Drag reduction via turbulent boundary layer flow control [PDF]
, 2017 The final publication is available at Springer via http://dx.doi.org/10.1007/s11431-016-9013-6Turbulent boundary layer control (TBLC) for skin-friction drag reduction is a relatively new technology made possible through the advances in computational ...
Zheng, Yao +15 more
core +1 more source
DNA hypermethylation/boundary control loss identified in retinoblastomas associated with genetic and epigenetic inactivation of the RB1 gene promoter. [PDF]
Epigenetics, 2021 Raizis AM +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
An ACA Accelerated isogeometric boundary element analysis of potential problems with non-uniform boundary conditions [PDF]
, 2017 This paper presents an Adaptive Cross Approximation (ACA) accelerated Isogeometric Boundary Element Method (IGBEM) using Non-Uniform Rational B-Splines (NURBS) as shape and interpolation functions. Provided that NURBS are used in CAD programs to describe
Campos, LS, Wrobel, LC, Albuquerque, EL
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source