Results 41 to 50 of about 19,207,286 (312)

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

A PDE Model Approach to Formation Control of Large-Scale Mobile Sensor Networks with Boundary Uncertainties

open access: yesAxioms, 2022
This paper investigates the formation problem of an array of large-scale mobile sensor networks. A new framework for the dynamic of mobile sensors as a continuum described by the parabolic system with boundary disturbance is proposed.
Xueming Qian, Baotong Cui
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

An Approximation of Solutions for the Problem with Quasistatic Contact in the Case of Dry Friction

open access: yesMathematics, 2021
In this paper, we discuss the question of finding an optimal control for the solutions of the problem with dry friction quasistatic contact, in the case that the friction law is modeled by a nonlocal version of Coulomb’s law.
Nicolae Pop   +2 more
doaj   +1 more source

On the Turnpike Phenomenon for Optimal Boundary Control Problems with Hyperbolic Systems [PDF]

open access: yesSIAM Journal of Control and Optimization, 2018
We study problems of optimal boundary control with systems governed by linear hyperbolic partial differential equations. The objective function is quadratic and given by an integral over the finite time interval $(0,\, T)$ that depends on the boundary ...
M. Gugat, Falk M. Hante
semanticscholar   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Boundary Control of a Vibrating String Subject to Input Saturation and Output Constraint

open access: yesIEEE Access, 2020
This paper presents a control framework of a vibrating flexible string system subject to input saturation and output constraint. By integrating the backstepping technique and Lyapunov theory, a smooth function, a Nussbaum function, a barrier function ...
Weijun Sun   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Vibration Boundary Control for a One-Dimensional Flexible Beam System With Restricted Input

open access: yesIEEE Access, 2018
This paper studies a boundary control problem of a 1-D flexible beam. The objective is to design an efficient boundary controller to suppress the undesired vibration of the 1-D flexible beam with restricted input. A novel boundary controller is developed
Zhijia Zhao   +4 more
doaj   +1 more source

Event-Based Boundary Control of a Linear $2\times 2$ Hyperbolic System via Backstepping Approach

open access: yesIEEE Transactions on Automatic Control, 2018
In this paper, we introduce an event-based boundary control for a $2\times 2$ coupled linear hyperbolic system. We use a well-established backstepping controller which stabilizes the system along with a dynamic triggering condition which determines when
Nicolás Espitia   +3 more
semanticscholar   +1 more source

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