Results 101 to 110 of about 1,481,716 (292)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

open access: yesMolecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David   +12 more
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

open access: yesMolecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Boundaries, Expectations and Empirical Research: A Commentary on Judith Becker's "Crossing Boundaries"

open access: yesEmpirical Musicology Review, 2009
In her paper “Crossing Boundaries”, Judith Becker raises and discusses important points about where various boundaries between different ways of studying music might lie, how we negotiate those boundaries, and some of the frustrations that ensue in ...
Eric Clarke
doaj   +1 more source

Learning in and across communities of practice: health professions education students' learning from boundary crossing. [PDF]

open access: yesAdv Health Sci Educ Theory Pract, 2022
Stoffels M   +5 more
europepmc   +1 more source

Stochastic boundary crossing probabilities for the Brownian motion

open access: yes, 2013
Using martingale methods, we derive a set of theorems of boundary crossing probabilities for a Brownian motion with different kinds of stochastic boundaries, in particular compound Poisson process boundaries.
Dassios, Angelos, Che, Xiaonan
core   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

open access: yesMolecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis   +20 more
wiley   +1 more source

Transboundary aquuifers and binantional ground water database for the city of El Paso / Ciudad Juarez area

open access: yes, 1998
This document integrates official ground-water data from the United States and Mexico into one data base. These data were exchanged during a series of official meetings held in the offices of the Comisión Internacional de Limites y Aguas and the ...
International Boundary and Water Commission (IBWC)
core  

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

open access: yesMolecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi   +2 more
wiley   +1 more source

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