Results 101 to 110 of about 23,409 (291)

Boundary integral based polygon wall representation in the MPS method

Nihon Kikai Gakkai ronbunshu, 2018
The particle methods are suited to simulate fluid flow problems with large boundary deformation. The moving particle semi-implicit (MPS) method is one of the representative particle methods for incompressible flow.
Takuya MATSUNAGA, Kazuya SHIBATA, Seiichi KOSHIZUKA   +2 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

A new periodic cell model of aerosol diffusion deposition in a fibrous filter

, 2021
A new periodic cell model for the convective-diffusive transport of small aerosol particles in a fibrous filter is developed. The proposed periodic model takes into account the influence of the fiber diffusion wake on the particle deposition. This allows
Mardanov R.F., Zaripov S.K., Sharafutdinov V.F.   +2 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

On the time-optimal control problem for a fourth order parabolic equation in a two-dimensional domain

Қарағанды университетінің хабаршысы. Математика сериясы
Previously, boundary control problems for the second order parabolic type equation in the bounded domain were studied. In this paper, a boundary control problem associated with a fourth-order parabolic equation in a bounded two-dimensional domain was ...
Ф.Н. Дехконов
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Localized direct segregated boundary-domain integral equations for variable-coefficient transmission problems with interface crack

, 2011
The full text of the published article can be accessed at the link belowSome transmission problems for scalar second order elliptic partial differential equations are considered in a bounded composite domain consisting of adjacent anisotropic subdomains ...
Mikhailov, SE, Natroshvili, D, Chkadua, O   +2 more
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

BEM for non-Newtonian fluid flow

, 2012
The main purpose of this work is to present the use of the boundary-domain integral method (BDIM) to analyse the flow behaviour of non-Newtoninan fluids.
Samec, Niko, Škerget, Leopold
core