Results 91 to 100 of about 1,137,021 (285)

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

A combined application of boundary-element and Runge-Kutta methods in three-dimensional elasticity and poroelasticity

EPJ Web of Conferences, 2015
The report presents the development of the time-boundary element methodology and a description of the related software based on a stepped method of numerical inversion of the integral Laplace transform in combination with a family of Runge-Kutta methods ...
Igumnov Leonid, Ipatov Aleksandr, Belov Aleksandr, Petrov Andrey   +3 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A boundary element alternating method for two-dimensional mixed-mode fracture problems [PDF]

A boundary element alternating method, denoted herein as BEAM, is presented for two dimensional fracture problems. This is an iterative method which alternates between two solutions.
Krishnamurthy, T., Raju, I. S.
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

An improved version of artificial boundary node approach

Computer Assisted Methods in Engineering and Science, 2022
This paper proposes an improvement of the artificial boundary node approach using the least square method. The original artificial boundary node approach requires the selection of an offset by the user.
Bahattin Kanber
doaj  

Combined creep and plastic analysis with numerical methods [PDF]

, 2013
The combination of plastic and creep analysis formulation are developed in this paper. The boundary element method and the finite element method are applied in plates in order to do the numerical analysis.
Kryvko, A., Pineda León, E., Zapata López, E.   +2 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Isogeometric boundary element method for solving 2D multi-media heat conduction problems

Results in Applied Mathematics
In this work, we employ the isogeometric boundary element approach to investigate heat transfer mechanisms in various media. We derive and construct integral equations for the interface of different media to address heat transfer issues.
Kunpeng Li, Wei Jiang, Haozhi Li
doaj   +1 more source

DETECTION OF AIR GAPS IN COPPER-MINE CEILING BY ELECTRICAL IMPEDANCE TOMOGRAPHY

Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska, 2017
In this paper, we investigate the inverse problem for the electric field so-called copper mine problem. In general, this task assumes detection of all air gaps. Gaps are localised above ceiling in a copper mine. Such task can be considered as application
Tomasz Rymarczyk, Paweł Tchórzewski, Jan Sikora   +2 more
doaj   +1 more source