Results 81 to 90 of about 13,967,028 (239)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Regularized singular boundary method for groundwater flow in a cofferdam

open access: yesMATEC Web of Conferences, 2018
The boundary integral methods form one group of methods for solving differential equations. The boundary element method (BEM) is the basic method of this group.
Mužík Juraj, Bulko Roman
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

open access: yesFEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés   +2 more
wiley   +1 more source

Prediction of waterjet excited underwater radiated noise by boundary element method

open access: yesZhongguo Jianchuan Yanjiu, 2017
Aiming to mitigate impact of the uncertain boundary conditions setting on the underwater radiated noise calculation, the numerical prediction method of calculating the underwater radiated noise of a waterjet by the one-step boundary element method was ...
LIU Qiang   +4 more
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

open access: yesFEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

An Interpolating Boundary Element-Free Method for Signorini problems

open access: yes四川大学学报. 自然科学版, 2016
Combining the improved interpolating moving least-square (IIMLS) method and boundary integral equations (BIEs), a novel boundary-only meshless method, the interpolating boundary element-free method (IBEFM), is developed for the numerical solution of ...
WANG Yan-Chong, LI Xiao-Lin
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An improved version of artificial boundary node approach

open access: yesComputer Assisted Methods in Engineering and Science, 2022
This paper proposes an improvement of the artificial boundary node approach using the least square method. The original artificial boundary node approach requires the selection of an offset by the user.
Bahattin Kanber
doaj  

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