Results 61 to 70 of about 121,834 (259)

Isogeometric Fast Multipole Boundary Element Method Based on Burton-Miller Formulation for 3D Acoustic Problems

open access: yesArchives of Acoustics, 2019
An isogeometric boundary element method is applied to simulate wave scattering problems governed by the Helmholtz equation. The NURBS (non-uniform rational B-splines) widely used in the CAD (computer aided design) field is applied to represent the ...
Leilei CHEN   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

A reduced-order boundary element method for two-dimensional acoustic scattering

open access: yesFrontiers in Physics
This study presents a novel method for wideband acoustic analysis using the Boundary Element Method (BEM), addressing significant computational challenges. Traditional BEM requires repetitive computations across different frequencies due to the frequency-
Senhao Zhong   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Regularized singular boundary method for groundwater flow in a cofferdam

open access: yesMATEC Web of Conferences, 2018
The boundary integral methods form one group of methods for solving differential equations. The boundary element method (BEM) is the basic method of this group.
Mužík Juraj, Bulko Roman
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Two-dimensional acoustic analysis using Taylor expansion-based boundary element method

open access: yesFrontiers in Physics
The use of boundary elements in two-dimensional acoustic analysis is presented in this study, along with a detailed explanation of how to derive the final discrete equations from the fundamental fluctuation equations.
Yan Yang   +5 more
doaj   +1 more source

Prediction of waterjet excited underwater radiated noise by boundary element method

open access: yesZhongguo Jianchuan Yanjiu, 2017
Aiming to mitigate impact of the uncertain boundary conditions setting on the underwater radiated noise calculation, the numerical prediction method of calculating the underwater radiated noise of a waterjet by the one-step boundary element method was ...
LIU Qiang   +4 more
doaj   +1 more source

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