Results 51 to 60 of about 13,967,028 (239)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

On the block wavelet transform applied to the boundary element method [PDF]

, 2004
This paper follows an earlier work by Bucher et al. [1] on the application of wavelet transforms to the boundary element method, which shows how to reuse models stored in compressed form to solve new models with the same geometry but arbitrary load cases
Bucher, HF, Wrobel, LC, Magluta, C, Mansur, WJ   +3 more
core   +1 more source

The Global Element Method for Three- Dimensional Potential Problems

IEEE Access
This paper presents the Global Element Method (GEM) for solving three-dimensional potential problems. Compared to traditional boundary element methods, this approach offers significant advantages.
Xinrong Li, Chao Zhang, Yaoming Zhang
doaj   +1 more source

A Computational Method for Acoustic Interaction with Large Complicated Underwater Structures Based on the Physical Mechanism of Structural Acoustics

Advances in Materials Science and Engineering, 2022
A numerical coupling approach is proposed to fast predict the acoustic radiation from a vibrating large-complicated underwater structure. In this study, the physical mechanism of sound radiation from underwater large target is used for the first time to ...
Yongzhuang Tang, Qidou Zhou, Xiaowei Wang, Zhiyong Xie   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Sensitivity analysis of non-uniform rational B-splines–based finite element/boundary element coupling in structural-acoustic design

Frontiers in Physics
For the purpose of modeling the acoustic fluid-structure interaction using direct differentiation method and conducting a structural-acoustic sensitivity analysis, a coupling approach based on the finite element method and the fast multipole boundary ...
Yanming Xu, Sen Yang, Sen Yang
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

RETRACTED : Composite parameters analysis with boundary element method

Journal of Materials and Engineering Structures, 2019
This article has been retracted at the request of the Editors-in-Chief, according to the Publication Ethics Policy and Publication Malpractice Statement.
Ahmed SAHLI, Fatiha ARAB MOHAMED, Sara SAHLI   +2 more
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source