Results 31 to 40 of about 121,458 (259)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

2D Structural Acoustic Analysis Using the FEM/FMBEM with Different Coupled Element Types

Archives of Acoustics, 2016
A FEM-BEM coupling approach is used for acoustic fluid-structure interaction analysis. The FEM is used to model the structure and the BEM is used to model the exterior acoustic domain.
Leilei CHEN, Wenchang ZHAO, Cheng LIU, Haibo CHEN   +3 more
doaj   +1 more source

A Computational Model for Nonlinear Biomechanics Problems of FGA Biological Soft Tissues

Applied Sciences, 2022
The principal objective of this work was to develop a semi-implicit hybrid boundary element method (HBEM) to describe the nonlinear fractional biomechanical interactions in functionally graded anisotropic (FGA) soft tissues.
Mohamed Abdelsabour Fahmy
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Boundary Element Method for the Helmholtz Equation

Journal of Mathematical Extension, 2015
The boundary element methos is applied to the Helholtltz equation. To this end we discretized the Helmholtz equation over the boundary Ω and conclude a system of equations.
A. Mesforush, Z. Mehraban
doaj  

A Computational Method for Acoustic Interaction with Large Complicated Underwater Structures Based on the Physical Mechanism of Structural Acoustics

Advances in Materials Science and Engineering, 2022
A numerical coupling approach is proposed to fast predict the acoustic radiation from a vibrating large-complicated underwater structure. In this study, the physical mechanism of sound radiation from underwater large target is used for the first time to ...
Yongzhuang Tang, Qidou Zhou, Xiaowei Wang, Zhiyong Xie   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Sliding frame-solid interaction using BEM/FEM coupling

Latin American Journal of Solids and Structures
In this work it is presented a coupling between the Boundary Element Method (BEM) and the Finite Element Method (FEM) for two-dimensional elastostatic analysis of frame-solid interaction.
Fabio Carlos da Rocha, Wilson Sergio Venturini, Humberto Breves Coda   +2 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source