Results 41 to 50 of about 3,344 (250)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Unsteady loss mechanisms in a boundary layer ingestion fan under inlet distortion

Flow
Boundary layer ingestion (BLI) propulsion can improve aircraft aerodynamic efficiency, but also introduces inlet distortion that affects fan flow and stability.
Junyang Yu, Yao Zhao, Yaning Feng, Xiangxin Zhou, Hanbo Jiang   +4 more
doaj   +1 more source

Techno-economic and environmental risk assessment of a turbo-electric distributed propulsion system on a blended wing body aircraft [PDF]

, 2014
Constant rise of air traffic has caused the environmental impacts of aviation to be the subject of an unprecedented scrutiny. Organisations all over the world are setting targets for emission reductions that represent the technological potential for ...
Giakoumakis, Eleftherios
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Experimental Parametric Investigation of the Haystacking Phenomenon for Propeller Boundary Layer Ingestion

, 2023
This database contains the datasets for the aeroacoustic experiments conducted at the University of Bristol regarding Boundary Layer Ingestion configurations A1 and A2 as part of the H2020 ENODISE project.
Falsi, Michele, Zaman, Ismaeel, Camussi, Roberto, Azarpeyvand, Mahdi, Zang, B.   +4 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Propulsive efficiency of boundary layer ingestion propellers

, 2018
The pursuit of lower fuel consumption for aircraft is promoting a departure from contemporary arrangements. One example is the development of more synergetic airframe and propulsion system designs, which are expected to increase significantly aircraft ...
Tomita, Jesuino Takachi, Costa, Fab\uedola Paula, Da Silva, Carlos Roberto Il\ue1rio, Bringhenti, Cleverson, Trapp, Gustavo, De Campos, Gustavo Bonolo, Gr\uf6nstedt, Tomas, Lundbladh, Anders, Capitao Patrao, Alexandre, Petit, Olivier   +9 more
core   +1 more source

A Fully Coupled Body Force-Engine Performance Methodology for Boundary Layer Ingestion [PDF]

, 2021
In reason of their potential improvements in fuel consumption, disruptive propulsion concepts such as Boundary Layer Ingestion are lately earning the attention of the aerospace community.
Garcia Rosa, Nicolas, López de Vega, Luis, Dufour, Guillaume   +2 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source