Results 51 to 60 of about 3,344 (250)

Optimising Blade Profiles to Extend the Operating Range in BLI Fan Application

open access: yesInternational Journal of Turbomachinery, Propulsion and Power
Boundary Layer Ingestion propulsors operate in an adverse aerodynamic environment with high levels of distortion. With the purpose of extending the operating range of transonic fan rotors for BLI applications, in this paper we present an optimisation ...
Andrea Magrini, Ernesto Benini
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

A comparative study of two-dimensional and three-dimensional ultrasonography in evaluation of gastric affections in dogs [PDF]

open access: yesVeterinary World, 2015
Aim: The objective of the study was to obtain and compare the two-dimensional (2D) and three-dimensional (3D) ultrasonographic images of pathological conditions of the stomach in dogs in clinical cases.
Madan Pal   +6 more
doaj   +1 more source

Analytical prediction of boundary layer ingestion noise for an integrated turbofan [PDF]

open access: yes, 2019
A parametric study based on the analytical predictions of tonal and broadband noise for a generic turbulent boundary layer interacting with the rotor of an ultra high bypass ratio fan is presented.
Moreau, Antoine   +2 more
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Multi-Fidelity Design Optimization of a Long-Range Blended Wing Body Aircraft with New Airframe Technologies

open access: yesAerospace, 2020
The German Cluster of Excellence SE²A (Sustainable and Energy Efficient Aviation) is established in order to investigate the influence of game-changing technologies on the energy efficiency of future transport aircraft.
Stanislav Karpuk, Yaolong Liu, Ali Elham
doaj   +1 more source

Distributed Propulsion featuring Boundary Layer Ingestion Engines for the Blended Wing Body Subsonic Transport

open access: yes, 2010
The blended wing body aircraft is one of the promising contenders for the next generation large transport aircraft. This aircraft is particularly suitable for the use of boundary layer ingestion engines.
Kok, H.J.M.   +8 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Performance analysis of turbo-electric propulsion system with fuselage boundary layer ingestion

open access: yes, 2021
A propulsion system analysis of an aircraft concept featuring a fuselage tail cone integrated turbo-electrically powered fan is presented. The aircraft has two underwing podded geared turbofan engines and an aft-fuselage mounted boundary layer ingesting ...
Grönstedt, Tomas,   +3 more
core   +1 more source

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