Results 61 to 70 of about 3,207,541 (303)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Mesure et Évaluation en Éducation, 2023 Face à des élèves qui cumulent les formes de vulnérabilités, les acteurs du lycée professionnel (LP) conçoivent des dispositifs éducatifs innovants, notamment pour l’évaluation.
Caroline Hache +3 more
doaj +1 more source
Ecodynamic design as a boundary object [PDF]
, 2011 Consensus in Dutch society is that the existing coastal defence regime is not sustainable. Adaptation is not only a technical challenge, but affects elements like ecology, cultural heritage, recreation, urban development, making the issue complex both ...
Slobbe, E.J.J., van
core
Regularizing variational methods for robust object boundary detection
, 2008 In this thesis, robust object boundary detection by the variational methods is studied. The variational methods fall into two categories: boundary-based and region based. This thesis focuses on the boundary-based variational methods.
Fang, Wen
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Jeu et non jeu dans les serious games
Sciences du Jeu, 2016 Claiming mix game and utilitarian goal, serious games tend to challenge traditional definitions of the game, free activity, separate and unproductive. For the researcher, they can be useful objects to query the boundary between what is a game and what is
Michel Lavigne
doaj +1 more source
Analysis of Model Results for the Turning of the Wind and Related Momentum Fluxes in the Stable Boundary Layer [PDF]
, 2009 The turning of wind with height and the related cross-isobaric (ageostrophic) flow in the thermally stable stratified boundary layer is analysed from a variety of model results acquired in the first Global Energy and Water Cycle Experiment (GEWEX ...
Svensson, G. +3 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source