Results 41 to 50 of about 199,828 (311)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Uniqueness in a two phase free boundary problem [PDF]
, 2001 We investigate a two-phase free-boundary problem in heat propagation that in classical terms is formulated as follows: to find a continuous function u(x, t) defined in a domain D ⊂ RN × (0, T) which satisfies the equation ∆u + Σ ai uxi − ut = 0 whenever ...
Lederman, Claudia Beatriz +2 more
core
On the solvability of a semi-periodic boundary value problem for the nonlinear Goursat equation
Қарағанды университетінің хабаршысы. Математика сериясы, 2021 In this paper, by means of a change of variables, a nonlinear semi-periodic boundary value problem for the Goursat equation is reduced to a linear gravity problem for hyperbolic equations. Reintroducing a new function, the obtained problem is reduced to
N.T. Orumbayeva +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Boundary problem for the singular heat equation
Karpatsʹkì Matematičnì Publìkacìï, 2017 The scheme for solving of a mixed problem with general boundary conditions is proposed for a heat equation \[a(x)\frac{\partial T}{\partial \tau}= \frac{\partial}{\partial x} \left(\lambda(x)\frac{\partial T}{\partial x}\right)\] with coefficient $a(x ...
O.V. Makhnei
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
DECREASING OF MECHANISMS DYNAMIC LOADING AT THE TRANSIENT STATE
Nauka ta progres transportu, 2015 Purpose. It is necessary to select modes of motion to reduce the dynamic loads in the mechanisms. This choice should be made on optimization basis. The purpose of research is to study methods of synthesis regimes of mechanisms and machines motion that ...
V. S. Loveikin, Yu. O. Romasevich
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Improved trial methods for a class of generalized Bernoulli problems [PDF]
, 2013 The aim of this article is to develop improved trial methods for the solution of a generalized exterior Bernoulli free boundary problem. At the free boundary, we prescribe the Neumann boundary condition and update the free boundary with the help of the ...
Mitrou, Giannoula, Harbrecht, Helmut
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Second-Order Boundary Value Problem with Integral Boundary Conditions
Boundary Value Problems, 2011 The nonlinear alternative of the Leray Schauder type and the Banach contraction principle are used to investigate the existence of solutions for second-order differential equations with integral boundary conditions.
Nieto JuanJ +2 more
doaj +2 more sources