Results 41 to 50 of about 1,259,915 (243)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Fullerene-water nanofluid confined in graphene nanochannel

AIP Advances, 2017
The flow behaviors and boundary slip of the fullerene-water nanofluids (NFs) confined in graphene nanochannels are first investigated by using classical molecular dynamics simulations.
Zhen Liu, Zhong-Qiang Zhang
doaj   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Basin-mountain tectonic pattern and hydrocarbon exploration domain in north margin of Qaidam Basin

Petroleum Exploration and Development, 2008
Seismic profile crossing southern boundary of Saishiteng Mountain shows the shear tectonic characteristic of fault zone at southern boundary of Saishiteng Mountain.
Gui-hong WANG, Da-de MA, Qi-quaxn ZHANG, Jun LI   +3 more
doaj   +1 more source

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

Advanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice, Krzysztof S. Stopka, Michael D. Sangid   +2 more
wiley   +1 more source

Nusselt Number Dependence on Friction Factor in the Boundary Slip Flow of a Newtonian Liquid Between Parallel Plates

Thermo
This study explored the relationship between the Nusselt number and the friction factor in the laminar boundary slip flow of a Newtonian liquid between parallel plates.
Krishna Kota, Sarada Kuravi, Prasanna Jayaramu   +2 more
doaj   +1 more source

Stagnation point flow and heat transfer over a nonlinear shrinking sheet with slip effects

Alexandria Engineering Journal, 2015
In this paper, an investigation is performed to analyze the effects of the slip parameters A and B on the steady stagnation-point flow and heat transfer due to a shrinking sheet in a viscous and incompressible fluid. Using similarity transformations, the
N.F. Fauzi, S. Ahmad, I. Pop
doaj   +1 more source

Microstructural Evolution and Vacancy Defect Formation in Mn–Mo–Ni RPV Steel Under Low Cycle Fatigue: Insights From EBSD and PALS

Advanced Engineering Materials, EarlyView.
Low‐cycle fatigue damage in Mn–Mo–Ni reactor pressure vessel steel is examined using a combined electron backscatter diffraction and positron annihilation lifetime spectroscopy approach. The study correlates texture evolution, dislocation substructure development, and vacancy‐type defect formation across uniform, necked, and fracture regions, providing
Apu Sarkar, Dhanadeep Dutta, G. Bharat Reddy   +2 more
wiley   +1 more source

Boundary Condition for the Electric Field in Earth's Core Models With Conducting Boundaries

Geophysical Research Letters
The Earth's core flows are governed by magnetohydrodynamic equations, where boundary conditions determine how the electric field in the liquid core relates to that in the conducting boundaries.
J. Rekier, S. A. Triana, B. Buffett
doaj   +1 more source