Results 31 to 40 of about 421,084 (235)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Boussinesq Systems of Bona-Smith Type on Plane Domains: Theory and Numerical Analysis [PDF]

, 2009
We consider a class of Boussinesq systems of Bona-Smith type in two space dimensions approximating surface wave flows modelled by the three-dimensional Euler equations.
Dougalis, Vassilios, Mitsotakis, Dimitrios, Saut, Jean-Claude   +2 more
core  

Transparent boundary conditions based on the Pole Condition for time-dependent, two-dimensional problems [PDF]

, 2012
The pole condition approach for deriving transparent boundary conditions is extended to the time-dependent, two-dimensional case. Non-physical modes of the solution are identified by the position of poles of the solution's spatial Laplace transform in ...
Alpert, Antoine, Astley, Bérenger, Ehrhardt, Engquist, Givoli, Givoli, Hagstrom, Hagstrom, Hagstrom, Hagstrom, Hagstrom, Hairer, Hohage, Hohage, Hohage, Lindman, Nannen, Nannen, Ruprecht, Schmidt, Schmidt, Schmidt, Schmidt, Tsynkov, Zschiedrich, Zschiedrich   +27 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Evolution PDEs and augmented eigenfunctions. I finite interval [PDF]

, 2013
The so-called unified method expresses the solution of an initial-boundary value problem for an evolution PDE in the finite interval in terms of an integral in the complex Fourier (spectral) plane.
Fokas, Athanassios S, Smith, David A
core   +1 more source

Evaluation of the stress singularities of plane V-notches in bonded dissimilar materials [PDF]

, 2008
According to the linear theory of elasticity, there exists a combination of different orders of stress singularity at a V-notch tip of bonded dissimilar materials. The singularity reflects a strong stress concentration near the sharp V-notches.
Ascher, Barsoum, Bogy, Carpenter, Carpinteri, Changzheng Cheng, Chen, Chue, Dali Ge, Delale, Fu, Gadi, Gladwell, Gross, Henshel, Hwu, Hwu, Jian, Jianqiao Ye, Labossiere, Li, Naman Recho, Niu, Pageau, Rzasnicki, Seweryn, Stern, Stroh, Sue, Tan, Ting, Ting, Wigger, Williams, Williams, Yosibash, Zhongrong Niu   +36 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

On the lowest by $x$-variable terms influence on the spectral properties of dirichlet problem for the hyperbolic systems

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2014
We made the comparison study and characterize the spectral properties of differential operators induced by the Dirichlet problem for the hyperbolic system without the lowest terms of the form $$ \cfrac{\partial^2{u^1}}{\partial{t}^2}+\cfrac{\partial^2{u ...
Olesya V Alexeeva, Vasiliy V Kornienko, Dmitriy V Kornienko   +2 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source