Results 21 to 30 of about 119,900,969 (241)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Non-homogeneous directional equations: Slice solutions belonging to functions of bounded $L$-index in the unit ball [PDF]

summary:For a given direction ${\bf b}\in \mathbb {C}^n\setminus \{{\bf 0}\}$ we study non-homogeneous directional linear higher-order equations whose all coefficients belong to a class of joint continuous functions which are holomorphic on intersection ...
Skaskiv, Oleh, Bandura, Andriy, Salo, Tetyana   +2 more
core   +1 more source

REMARKS ON SOME CLASSES OF POSITIVE CONTINUOUS FUNCTIONS IN C^n

, 2021
Here we prove two propositions providing sufficient conditions of belonging positive continuous functions in  to classes  and  These auxiliary classes plays important role in theory of entire functions of bounded L-index in direction and bounded L-index ...
А. І. Bandura
semanticscholar   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Boundedness of l-index in direction of functions of the form $f(\langle z,m\rangle)$ and existence theorems

Matematychni Studii, 2014
A. I. Bandura, O. B. Skaskiv. Boundedness of l-index in direction of functions of the form f(〈z,m〉) and existence theorems, Mat. Stud. 41 (2014), 45–52. We obtain a criterion of boundedness of L-index in direction for functions f(〈z,m〉).
Andriy Ivanovych Bandura, O. Skaskiv
semanticscholar   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Adaptive detection with bounded steering vectors mismatch angle [PDF]

, 2007
We address the problem of detecting a signal of interest (SOI), using multiple observations in the primary data, in a background of noise with unknown covariance matrix.
Besson, Olivier
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source