Results 101 to 110 of about 70,365 (263)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, EarlyView.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

Cellular Snowballing: Cell Adhesion and Migration Drive the Self‐Assembly of Cell‐Microgel Biohybrid Spheroids

Advanced Science, EarlyView.
A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie, Sina Kheirabadi, Changhao Li, Aneesh Risbud, Aswathy Sebastian, Istvan Albert, Sulin Zhang, Amir Sheikhi   +7 more
wiley   +1 more source

Time‐Resolved SAXS Reveals Distinct Millisecond Metal‐Induced Conformational Dynamics of Monomeric α‐Synuclein

Advanced Science, EarlyView.
Time‐resolved SAXS reveals how physiologically relevant metal ions shape the earliest conformational responses of monomeric α‐synuclein. Fe3+ induces rapid compaction, Cu2+ generates heterogeneous and partially folded ensembles, while Mn2+ and Zn2+ cause only modest changes.
Rebecca Sternke‐Hoffmann, Miriam Dos Santos Pinto, Xue Wang, Jinghui Luo   +3 more
wiley   +1 more source

Existence of weak solutions for nonlinear elliptic systems on $R^N$

Electronic Journal of Differential Equations, 2006
In this paper, we consider the nonlinear elliptic system $$displaylines{ -Delta_pu=a(x)|u|^{p-2}u-b(x)|u|^alpha|v|^eta v+f,cr -Delta_qv=-c(x)|u|^alpha |v|^eta u + d(x) |v|^{q-2}v +g ,cr lim_{|x|oinfty}u=lim_{|x|oinfty}v=0quad u,v>0 }$$ on a ...
Eada A. El-Zahrani, Hassan M. Serag
doaj  

Perturbation of Weyl’s Theorems for Unbounded  Upper Triangular Operator Matrices

Ibn Al-Haitham Journal for Pure and Applied Sciences
Let  be an upper triangular operator matrix which is unbounded and defined on , where  is infinite dimensional Hilbert space. This paper is concerned with new spectral properties which defined to other bounded operators.
Dalia S. Ali, Buthainah A.A. Ahmed
doaj   +1 more source

Radical‐Mediated, Substrate‐Independent Fabrication of Hybrid Solid–Hydrogel Materials With Tunable Crosslinking: An Initiator‐ and Crosslinker‐Free Approach

Advanced Science, EarlyView.
This work introduces a substrate‐independent, reagent‐free plasma strategy that forms radical‐rich interlayers for covalent hydrogel attachment without initiators or crosslinkers. The long‐lived radicals drive in situ gelation, creating robust, cytocompatible hybrid solid–hydrogel constructs across diverse substrates.
Ghazal Shineh, Azin Khodaei, Pardis Keikhosravani, Masoud Zhianmanesh, Yiyun Xia, Aaron Gilmour, Sina Naficy, Andrea Guzina, Daniella Bianchi, Khoon S. Lim, Fariba Dehghani, Saber Amin Yavari, Marcela Bilek, Giselle C. Yeo, Behnam Akhavan   +14 more
wiley   +1 more source

Bilinear control of evolution equations with unbounded lower order terms. Application to the Fokker–Planck equation

Comptes Rendus. Mathématique
We study the exact controllability of the evolution equation \begin{equation*} u^{\prime }(t)+Au(t)+p(t)Bu(t)=0 \end{equation*} where $A$ is a nonnegative self-adjoint operator on a Hilbert space $X$ and $B$ is an unbounded linear operator on $X ...
Alabau-Boussouira, Fatiha, Cannarsa, Piermarco, Urbani, Cristina   +2 more
doaj   +1 more source

Noncoercive Perturbed Densely Defined Operators and Application to Parabolic Problems

Abstract and Applied Analysis, 2015
Let X be a real locally uniformly convex reflexive separable Banach space with locally uniformly convex dual space X∗. Let T:X⊇D(T)→2X∗ be maximal monotone and S:X⊇D(S)→X∗ quasibounded generalized pseudomonotone such that there exists a real reflexive ...
Teffera M. Asfaw
doaj   +1 more source

Dirichlet-to-Neumann Maps, Abstract Weyl-Titchmarsh $M$-Functions, and a Generalized Index of Unbounded Meromorphic Operator-Valued Functions

, 2016
We introduce a generalized index for certain meromorphic, unbounded, operator-valued functions. The class of functions is chosen such that energy parameter dependent Dirichlet-to-Neumann maps associated to uniformly elliptic partial differential ...
Behrndt, Jussi, Gesztesy, Fritz, Holden, Helge, Nichols, Roger   +3 more
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