Results 131 to 140 of about 1,242,956 (315)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Multivalence of bivariate functions of bounded index
Le Matematiche, 2015 This paper examines the relationship between the concept of bounded index and the radius of equivalence, respectively p-valence, of entire bivariate functions and their partial derivatives at arbitrary points in C^2.
Fatih Nuray, Richard F. Patterson
doaj
New Approximation Formula of Digamma Function with Bounded Remainder
MathematicsThis study establishes the new approximation formula for the Digamma function ψ(s)=lns−12s−112ss2+θ(s ...
Mansour Mahmoud +2 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Bounding Computational Complexity under Cost Function Scaling in Predictive Control [PDF]
, 2019 Ian McInerney +2 more
openalex +1 more source
Results in Mathematics, 2017 We improve the upper bound of the following inequalities for the gamma function $ $ due to H. Alzer and the author. \begin{equation*} \exp\left(-\frac{1}{2} (x+1/3)\right)
openaire +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
On the Solvability of the Identification Problem for a Source Function in a Quasilinear Parabolic System of Equations in Bounded and Unbounded Domains [PDF]
, 2001 Вера Г. Копылова +1 more
openalex +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source