Results 131 to 140 of about 13,126,261 (396)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Classes of graphs with small rank decompositions are chi-bounded [PDF]

arXiv, 2011
A class of graphs G is chi-bounded if the chromatic number of graphs in G is bounded by a function of the clique number. We show that if a class G is chi-bounded,then every class of graphs admitting a decomposition along cuts of small rank to graphs from G is chi-bounded.
arxiv  

Lower bound functions for polynomials

Journal of Computational and Applied Mathematics, 2003
AbstractRelaxation techniques for solving nonlinear systems and global optimisation problems require bounding from below the nonconvexities that occur in the constraints or in the objective function by affine or convex functions. In this paper we consider such lower bound functions in the case of problems involving multivariate polynomials.
Garloff, Jürgen, Jansson, Christian, Smith, Andrew Paul   +2 more
openaire   +3 more sources

Approximation by Superpositions of a Sigmoidal Function

, 2003
We generalize a result of Gao and Xu [4] concerning the approximation of functions of bounded variation by linear combinations of a fixed sigmoidal function to the class of functions of bounded φ-variation (Theorem 2.7). Also, in the case of one variable,
G. Lewicki, G. Marino
semanticscholar   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Precompactness in bivariate metric semigroup-valued bounded variation spaces [PDF]

arXiv
In this paper, we show that if a set in bivariate metric semigroups-valued bounded variation spaces is pointwise totally bounded and joint equivariated then it is precompact. These spaces include bounded Jordan variation spaces, bounded Wiener variation spaces, bounded Waterman variation spaces, bounded Riesz variation spaces and bounded Korenblum ...
arxiv  

On the differentiability of functions of bounded variation [PDF]

, 1936
Bohuš Jurek
openalex   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Multilinear Square Functions with Kernels of Dini’s Type

Journal of Function Spaces, 2016
Let T be a multilinear square function with a kernel satisfying Dini(1) condition and let T⁎ be the corresponding multilinear maximal square function. In this paper, first, we showed that T is bounded from L1×⋯×L1 to L1/m,∞. Secondly, we obtained that if
Zengyan Si, Qingying Xue
doaj   +1 more source

On order-bounded subsets of locally solid Riesz spaces [PDF]

arXiv, 2014
In a topological Riesz space there are two types of bounded subsets: order bounded subsets and topologically bounded subsets. It is natural to ask (1) whether an order bounded subset is topologically bounded and (2) whether a topologically bounded subset is order bounded.
arxiv