Results 131 to 140 of about 1,241,136 (285)
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Almost bounded functions [PDF]
Transactions of the American Mathematical Society, 1955 openaire +2 more sources
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Majorization bounds for distribution functions
Statistics & Probability Letters, 2012 Let $X$ be a random variable with distribution function $F,$ and $X_{1},X_{2},...,X_{n}$ are independent copies of $X.$ Consider the order statistics $X_{i:n},$ $i=1,2,...,n$ and denote $F_{i:n}(x)=P\{X_{i:n}\leq x\}.$ Using majorization theory we write upper and lower bounds for $F$ expressed in terms of mixtures of distribution functions of order ...
openaire +3 more sources
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
LOCALLY BOUNDED FUNCTIONS [PDF]
Real Analysis Exchange, 1997 null Mimna, null Wingler
openaire +3 more sources
Symbolic computation of Appell polynomials using Maple
Electronic Journal of Differential Equations, 2001 This work focuses on the symbolic computation of Appell polynomials using the computer algebra system Maple. After describing the traditional approach of constructing Appell polynomials, the paper examines the operator method of constructing the same ...
H. Alkahby +3 more
doaj
Boundedness of Variance Functions of Natural Exponential Families with Unbounded Support
MathematicsThe variance function (VF) is central to natural exponential family (NEF) theory. Prompted by an online query about whether, beyond the classical normal NEF, other real-line NEFs with bounded VFs exist, we establish three complementary sets of sufficient
Shaul K. Bar-Lev
doaj +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source