Results 141 to 150 of about 1,815,702 (357)
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
The anterior nucleus of the thalamus plays a role in the epileptic network
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2010-2024, December 2022., 2022 Abstract Objectives We investigated both the metabolic differences and interictal/ictal discharges of the anterior nucleus of the thalamus (ANT) in patients with epilepsy to clarify the relationship between the ANT and the epileptic network. Methods Nineteen patients with drug‐resistant epilepsy who underwent stereoelectroencephalography were studied ...
Hao Yan +9 more
wiley +1 more source
Multilinear Square Functions with Kernels of Dini’s Type
Journal of Function Spaces, 2016 Let T be a multilinear square function with a kernel satisfying Dini(1) condition and let T⁎ be the corresponding multilinear maximal square function. In this paper, first, we showed that T is bounded from L1×⋯×L1 to L1/m,∞. Secondly, we obtained that if
Zengyan Si, Qingying Xue
doaj +1 more source
What Hilbert spaces can tell us about bounded functions on the bidisk [PDF]
arXiv, 2009 We discuss various theorems about bounded analytic functions on the bidisk that were proved using operator theory.
arxiv
On Definitions of Bounded Variation for Functions of Two Variables [PDF]
, 1933 James A. Clarkson, C. Raymond Adams
openalex +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Demonstratio Mathematica, 2019 In the paper we investigate slice holomorphic functions F : ℂn → ℂ having bounded L-index in a direction, i.e. these functions are entire on every slice {z0 + tb : t ∈ℂ} for an arbitrary z0 ∈ℂn and for the fixed direction b ∈ℂn \ {0}, and (∃m0 ∈ ℤ+) (∀m ∈
Bandura Andriy +2 more
doaj +1 more source
Mapping Hsp104 interactions using cross‐linking mass spectrometry
FEBS Open Bio, EarlyView.This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal +3 more
wiley +1 more source
Bounds on the bias terms for the Markov reward approach [PDF]
arXiv, 2019 An important step in the Markov reward approach to error bounds on stationary performance measures of Markov chains is to bound the bias terms. Affine functions have been successfully used for these bounds for various models, but there are also models for which it has not been possible to establish such bounds.
arxiv