Results 31 to 40 of about 150,251 (161)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Hayman’s theorem for analytic functions in a complete Reinhardt domain

open access: yesМатематичні Студії
For functions analytic in a complete multiple circular domain $\mathbb{G}\subset\mathbb{C}^n$ there are established a counterpart of Haymans' Theorem.
T. M. Salo
doaj   +1 more source

Sequential Monte Carlo smoothing for general state space hidden Markov models

open access: yes, 2011
Computing smoothing distributions, the distributions of one or more states conditional on past, present, and future observations is a recurring problem when operating on general hidden Markov models.
Douc, Randal   +4 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Bounds on the Capacity of the Relay Channel with Noncausal State at Source

open access: yes, 2011
We consider a three-terminal state-dependent relay channel with the channel state available non-causally at only the source. Such a model may be of interest for node cooperation in the framework of cognition, i.e., collaborative signal transmission ...
Piantanida, Pablo   +3 more
core   +4 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Estimation of the Memory Parameter of the Infinite Source Poisson Process

open access: yes, 2007
Long-range dependence induced by heavy tails is a widely reported feature of internet traffic. Long-range dependence can be defined as the regular variation of the variance of the integrated process, and half the index of regular variation is then ...
Fay, Gilles   +2 more
core   +4 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Dominating polynomial in power series expansion for analytic functions in a complete Reinhardt domain

open access: yesМатематичні Студії
We generalized some criteria of boundedness of $\mathbf{L}$-index in joint variables for analytic functions in a complete multiple circular domain, where $\mathbf{L}(z)=(l_1(z_1,z_2,\ldots,z_n),$ $l_{2}(z_1,z_2,\ldots,z_n),$ $\ldots,$ $l_{n}(z_1,z_2 ...
A. I. Bandura, T.M. Salo
doaj   +1 more source

The Non-Regular CEO Problem

open access: yes, 2015
We consider the CEO problem for non-regular source distributions (such as uniform or truncated Gaussian). A group of agents observe independently corrupted versions of data and transmit coded versions over rate-limited links to a CEO.
Varshney, Lav R., Vempaty, Aditya
core   +1 more source

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