Results 121 to 130 of about 3,723,489 (302)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Context-bounded model checking of LTL properties for ANSI-C software
, 2011 Context-bounded model checking has successfully been used to verify safety properties in multi-threaded systems automatically, even if they are implemented in low-level programming languages like ANSI-C.
Denis Nicole +8 more
core +1 more source
Heteroclinic solutions to an asymptotically autonomous second-order equation
Electronic Journal of Differential Equations, 2010 We study the differential equation $ddot{x}(t) = a(t)V'(x(t))$, where $V$ is a double-well potential with minima at $x = pm 1$ and $a(t) o l > 0$ as $|t| o infty$.
Gregory S. Spradlin
doaj
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A minority game with bounded recall. [PDF]
This paper studies a repeated minority game with public signals, symmetric bounded recall, and pure strategies. We investigate both public and private equilibria of the game with fixed recall size.
Renault, Jérôme +2 more
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Structural stability and robustness to bounded rationality [PDF]
The introduction of a small amount of bounded rationality into a model sometimes has little effect, and sometimes has a dramatic impact on predicted behavior.
Canning, David, Anderlini, Luca
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Ultracontractive bounds on Hamilton–Jacobi solutions
Bulletin des Sciences Mathématiques, 2002 The main results of this paper concern the border of three theorems, which are respectively the theorem of hypercontractivity of Gross, the theorem of hypercontractivity of Bobkov-Gentil-Ledoux and the theorem of ultracontractivity of Varopoulos. Following the equivalence between logarithmic Sobolev inequality, hypercontractivity of the heat semigroup ...
openaire +1 more source