Results 131 to 140 of about 3,723,489 (302)

Positive solutions for nonlinear elliptic systems

open access: yesElectronic Journal of Differential Equations, 2012
In this article, we study the existence of positive solutions for the system $$displaylines{ Delta u=H(x,u,v),cr Delta v=K(x,u,v),hbox{in }mathbb{R}^n; (ngeq 3), }$$ where $H,K: mathbb{R}^nimes[0,infty)imes[0,infty)o[0,infty)$ are continuous ...
Adel Ben Dekhil
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

A note on the existence of Psi-bounded solutions for a system of differential equations on R

open access: yesElectronic Journal of Differential Equations, 2008
We prove a necessary and sufficient condition for the existence of Psi-bounded solutions of a linear nonhomogeneous system of ordinary differential equations on R.
Aurel Diamandescu
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Uniqueness of bounded flow solution in aerodynamics

open access: yes, 1998
{We discuss uniqueness for steady incompressible inviscid flows past a body with a sharp trailing edge TE, with particular regard to multiconnected (toroidal) 3D wing configurations.
LANCIA, Maria Rosaria   +3 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

An extension of bounded-input-bounded-output stability

open access: yes, 1970
A new type of stability definition is formulated that is quite similar to bounded-input-bounded-output stability, but offers certain conceptual ...
Vidyasagar, M.
core   +1 more source

Bounded Approximate Decentralised Coordination using the Max-Sum Algorithm

open access: yes, 2009
In this paper we propose a novel algorithm that provides bounded approximate solutions for decentralised coordination problems. Our approach removes cycles in any general constraint network by eliminating dependencies between functions and variables ...
Jennings, Nick   +2 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

The Simonian bounded rationality hypothesis and the expectation formation mechanism [PDF]

open access: yes
. In the 1980s and at beginning of the 1990s the debate on expectation formation mechanism was dominated by the rational expectation hypothesis. Later on, more interest was directed towards alternative approaches to expectations analysis, mainly based on
Kowalski, Tadeusz
core  

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