Bounded positive solutions of Schrödinger equations
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Improved bounds for solutions of ϕ-Laplacians
Summary: In this short paper we prove a parametric version of the Harnack inequality for \(\phi\)-Laplacian equations. In this sense, the estimates are optimal and represent an improvement of previous bounds for this kind of operators.
Waldo Arriagada, Jorge Huentutripay
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
On the Lp-differentiability of certain classes of functions [PDF]
We prove the $L^p$-differentiability at almost every point for convolution products on $R^d$ of the form $K*\mu$, where $\mu$ is bounded measure and $K$ is a homogeneous kernel of degree $1-d$.
Crippa, Gianluca +7 more
core +1 more source
Boundedness and almost periodicity for some state-dependent delay differential equations
This work is devoted to the study the existence and uniqueness of bounded solutions for state-dependent delay differential equations. We also study the existence of periodic and almost periodic solutions.
El Hadi Ait Dads, Khalil Ezzinbi
doaj
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
BOUNDED SOLUTIONS OF NONLINEAR DIFFERENCE EQUATIONS
Bounded solutions of nonlinear difference equations.
Cheng, Sui Sun, Li, Horng Jaan
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Translophagy—A potential link between autophagy impairment and translational errors
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source

