Results 91 to 100 of about 61,672 (299)
On system operators with variation bounding properties
AutomaticaThe property of linear discrete-time time-invariant system operators mapping inputs with at most $k-1$ sign changes to outputs with at most $k-1$ sign changes is investigated. We show that this property is tractable via the notion of $k$-sign consistency in case of the observability/controllability operator, which as such can also be used as a ...
Christian Grussler +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
, 2006 In this paper, we establish some generalizations of weighted Ostrowski type Inequalities, and give several applications for r−moments, expectation of a continuous random variable and the Beta ...
Hwang, Shiow-Ru +3 more
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Differences Between Means with Bounds from a Riemann-Stieltjes Integral
, 2001 An identity for the difference between two integral means is obtained in terms of a Riemann-Stieltjes integral.
Cerone, Pietro, Dragomir, Sever S
core
, 2004 In this paper, we establish some generalizations of weighted trapezoid inequality for mappings of bounded variation, and give several applications for r-moment, the expectation of a continuous random variable and the Beta mapping ...
Kuei-Lin Tseng +3 more
core +1 more source
On integral bounded variation [PDF]
Revista de la Real Academia de Ciencias Exactas, Físicas y Naturales. Serie A. Matemáticas, 2017 The notion of \(q\)-integral \(p\)-variation, being an integral counterpart of Wiener's \(p\)-variation, has been introduced by \textit{A. P. Terehin} [Math. USSR, Sb. 17, 279--288 (1973; Zbl 0262.26011); translation from Mat. Sb., n. Ser. 88(130), 277--286 (1972)].
openaire +2 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source