Results 81 to 90 of about 552,211 (279)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Regularity of one-sided multilinear fractional maximal functions
Open Mathematics, 2018 In this paper we introduce and investigate the regularity properties of one-sided multilinear fractional maximal operators, both in continuous case and in discrete case.
Liu Feng, Xu Lei
doaj +1 more source
Acta Scientiarum: Technology, 2013 In this paper we have introduced the notion of fuzzy real-valued p-bounded variation double sequence space 2bvp/F(1 ≤ p < ∞). We have studied some important properties like completeness, convergence free, solid, symmetric.
Amar Jyoti Dutta
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Functions with bounded E-d-variation on undirected tree networks
Journal of Numerical Analysis and Approximation Theory, 2002 In this paper we define and study functions with bounded \(E-d\)-variation on undirected tree networks. For these functions with bounded \(E-d\)-variation we establish a Jordan type theorem.
Daniela Marian
doaj +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Integral operators in the spaces of functions of bounded Schramm variation
Journal of Inequalities and ApplicationsIn this paper we provide a full characterization of linear integral operators acting from the space of functions of bounded Jordan variation to the space of functions of bounded Schramm variation in terms of their generating kernels.
Jacek Gulgowski +2 more
doaj +1 more source