Results 131 to 140 of about 18,644 (317)

BOUNDEDNESS AND EXISTENCE ANALYSIS SOLUTION OF AN OPTIMAL CONTROL PROBLEMS ON MATHEMATICAL COVID-19 MODEL

open access: yesBarekeng
The investigation given right here is part of a literature review on mathematical models that apply analytical mathematics. The present work focuses on the COVID-19 model, which incorporates optimum control variables previously investigated and ...
Lukman Hakim, Lilis Widayanti
doaj   +1 more source

Boundedness of Limits [PDF]

open access: yesProceedings of the American Mathematical Society, 1962
openaire   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Boundedness in Asymmetric Oscillations

open access: yesJournal of Mathematical Analysis and Applications, 1999
The equation \(x''+ ax^+- bx^-= f(t)\) is studied where \(f(t)\) is a \(2\pi\)-periodic function, \(a\) and \(b\) are positive constants such that \(a\neq b\). It is shown that under some assumptions, all solutions to the equation are bounded, more precisely, if \(x(t)\) is a solution to the equation, then it is defined for all \(t\in \mathbb{R}\), and
openaire   +2 more sources

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

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