Results 111 to 120 of about 18,644 (317)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Generalized practical stability of Hopfield-type neural networks differential equations

Mathematical Modelling and Analysis
This paper investigates the boundedness and practical stability properties of solutions for a class of neural differential equations inspired by Hopfield-type neural networks.
Hanen Damak, Mohamed Ali Hammami
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A priori and a posteriori estimates for solving one evolutionary inverse problem

Учёные записки Казанского университета: Серия Физико-математические науки
This article considers an initial-boundary value problem for a system of parabolic equations, which arises when studying the flow of a binary mixture in a horizontal channel with walls heated non-uniformly.
V. K. Andreev, I. V. Stepanova
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Boundedness and asymptotic stability in a chemotaxis model with indirect signal production and logistic source

Electronic Journal of Differential Equations, 2022
Xiaobing Ye, Liangchen Wang
doaj  

Behavior of solutions of a discrete population model with mutualistic interaction

Computational and Mathematical Biophysics
We focus on the stability analysis of two types of discrete dynamic models: a discrete dynamic equation and a discrete dynamics system consisting of two equations with mutualistic interaction given by xn+1=a+bxnλ−(xn−1+xn−k)c+xn−1+xn−k{x}_{n+1}=a+\frac{b{
Babu Sibi C., Dilip D. S., Mathew Smitha Mary   +2 more
doaj   +1 more source

Nikodym boundedness property for webs in $$\sigma $$ σ -algebras [PDF]

, 2015
Salvador López-Alfonso, J. Mas, Salvador Moll   +2 more
openalex   +1 more source

Local boundedness for $p$-Laplacian with degenerate coefficients [PDF]

, 2022
Peter Bella, Mathias Schäffner
openalex   +1 more source

A survey of degree-boundedness

European Journal of Combinatorics
Suppose a graph has no large balanced bicliques, but has large minimum degree. Then what can we say about its induced subgraphs? This question motivates the study of degree-boundedness, which is like $χ$-boundedness but for minimum degree instead of chromatic number. We survey this area with an eye towards open problems.
Xiying Du, Rose McCarty
openaire   +3 more sources