Results 171 to 180 of about 1,465,298 (295)

OCT5k: A dataset of multi-disease and multi-graded annotations for retinal layers. [PDF]

Sci Data
Arikan M, Willoughby J, Ongun S, Sallo F, Montesel A, Ahmed H, Hagag A, Book M, Faatz H, Cicinelli MV, Fawzi AA, Podkowinski D, Cilkova M, De Almeida DM, Zouache M, Ramsamy G, Lilaonitkul W, Dubis AM.   +17 more
europepmc   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

End-to-end 3D instance segmentation of synthetic data and embryo microscopy images with a 3D Mask R-CNN. [PDF]

Front Bioinform
David G, Faure E.
europepmc   +1 more source

Microenvironment‐Guided Evolution of ssDNA‐SWCNT Probes for Selective Recognition of Aggressive Prostate Cancer Phenotypes

Advanced Science, EarlyView.
Random ssDNA–SWCNT(single strand DNA‐single walled carbon nanotube) library is functionally screened and evolved using high‐throughput 3D prostate tumor spheroids via iterative positive and negative selection, enabling the identification of NIR‐II fluorescent ssDNA‐SWCNT nanoprobe specific for prostate cancer.
Dakyeon Lee, Seok‐Hyeon Lee, Yunseo Jung, Jeongho Lee, Min‐Seo Choi, SaeOck Oh, Sungjee Kim, Byoung Soo Kim, Sanghwa Jeong   +8 more
wiley   +1 more source

Biomechanics‐Driven 3D Architecture Inference from Histology Using CellSqueeze3D

Advanced Science, EarlyView.
CellSqueeze3D reconstructs 3D cellular architecture from standard 2D histology images using biomechanical constraints and optimization. Validated on clinical datasets, it enables accurate tissue phenotyping, predicts gene mutations, and reveals significant correlations between nuclear‐cytoplasmic ratio entropy and tumor progression.
Yan Kong, Hui Lu
wiley   +1 more source

In silico assessment of nanoparticle toxicity powered by the Enalos Cloud Platform: Integrating automated machine learning and synthetic data for enhanced nanosafety evaluation. [PDF]

Comput Struct Biotechnol J
Varsou DD, Kolokathis PD, Antoniou M, Sidiropoulos NK, Tsoumanis A, Papadiamantis AG, Melagraki G, Lynch I, Afantitis A.   +8 more
europepmc   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

An Intelligent Magneto‐Mechanical Platform for Cellular Sensing in 3D Microenvironments

Advanced Science, EarlyView.
This study presents MagMI, a pioneering machine intelligence‐driven magneto‐mechanical sensing platform. It utilizes magneto‐mechanical arrays and machine learning to achieve label‐free, real‐time monitoring and classification of cellular proliferation dynamics within 3D microenvironments.
Yue Quan, Yuxin Wang, Sen Ding, Bingpu Zhou, Yinning Zhou   +4 more
wiley   +1 more source

GPU Ray Tracing for the Analysis of Light Deflection in Inhomogeneous Refractive Index Fields of Hot Tailored Forming Components. [PDF]

Sensors (Basel)
Kern P, Brower-Rabinowitsch M, Hinz L, Kästner M, Reithmeier E.   +4 more
europepmc   +1 more source

Orientation‐Dependent Phase Transformation Pathways Enabling Superior Superelastic and Elastocaloric Performance of NiTi Alloys

Advanced Science, EarlyView.
By integrating simulations and experiments, the preferred (001) crystallographic texture promotes reversible martensite formation through variant selection, enhancing both superelastic and elastocaloric performance. This work provides fundamental guidelines for designing high‐efficiency NiTi‐based functional materials. Abstract Developing elastocaloric
Jiaqi Lu, Muhammad Aziz, Hao Li, Chi Zhang, Zhifeng Huang, Fei Chen   +5 more
wiley   +1 more source