Results 41 to 50 of about 1,465,298 (295)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Hybrid bounds for automorphic forms on ellipsoids over number fields [PDF]

Journal of the Institute of Mathematics of Jussieu, 2012
AbstractWe prove upper bounds for Hecke–Laplace eigenfunctions on certain Riemannian manifolds $X$ of arithmetic type, uniformly in the eigenvalue and the volume of the manifold. The manifolds under consideration are $d$-fold products of $2$-spheres or $3$-spheres, realized as adelic quotients of quaternion algebras over totally real number fields.
Blomer Valentin, Michel Philippe
openaire   +4 more sources

Ellipsoidal constrained state estimation in presence of bounded disturbances [PDF]

2021 European Control Conference (ECC), 2021
This contribution proposes a recursive, computationally efficient, ready-to-use, online method for the ellipsoidal state characterization for linear discrete-time models with additive unknown disturbances vectors (bounded by known possibly degenerate zonotopes) corrupting both the state difference equation and the sporadic measurement vectors, which ...
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Approximating Hereditary Discrepancy via Small Width Ellipsoids

, 2014
The Discrepancy of a hypergraph is the minimum attainable value, over two-colorings of its vertices, of the maximum absolute imbalance of any hyperedge.
Nikolov, Aleksandar, Talwar, Kunal
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Lightweight Implicit Approximation of the Minkowski Sum of an N-Dimensional Ellipsoid and Hyperrectangle

Mathematics
This work considers the Minkowski sum of an N-dimensional ellipsoid and hyperrectangle, a combination that is extremely relevant due to the usage of ellipsoid-adjacent primitives in computer graphics for work such as 3D Gaussian splatting.
Martijn Courteaux, Bert Ramlot, Peter Lambert, Glenn Van Wallendael   +3 more
doaj   +1 more source

On Reachable Sets of Hidden CPS Sensor Attacks

, 2017
For given system dynamics, observer structure, and observer-based fault/attack detection procedure, we provide mathematical tools -- in terms of Linear Matrix Inequalities (LMIs) -- for computing outer ellipsoidal bounds on the set of estimation errors ...
adams, aström, cardenas, chen, cárdenas, giraldo, guo, hadizadeh, hashemi, kyriakides, luenberger, murguia, ross, scherer, tunga, van dobben de bruyn   +15 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

The Geometry of Differential Privacy: the Sparse and Approximate Cases

, 2012
In this work, we study trade-offs between accuracy and privacy in the context of linear queries over histograms. This is a rich class of queries that includes contingency tables and range queries, and has been a focus of a long line of work. For a set of
Nikolov, Aleksandar, Talwar, Kunal, Zhang, Li   +2 more
core   +1 more source