Results 51 to 60 of about 6,910,975 (305)
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Balance-Of-Payments-Constrained Growth Model: Empirical Evidence from Malaysia
International Journal of Management Studies, 2005 Applying cointegration approach, the present study aims to examine the validity of the Harrod Thirlwall balance-of-payments-constrained growth model in Malaysia.
Tuck Cheong Tang
doaj
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Information-Theoretic Generalization Bounds for Meta-Learning and Applications
Entropy, 2021 Meta-learning, or “learning to learn”, refers to techniques that infer an inductive bias from data corresponding to multiple related tasks with the goal of improving the sample efficiency for new, previously unobserved, tasks.
Sharu Theresa Jose, Osvaldo Simeone
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Public debt and inflation nexus in Nigeria: An ARDL bounds test approach
Cogent Economics & Finance, 2021 Inflationary tendencies of public debt have been the cause of an unsettling debate among policymakers in Nigeria. Using the autoregressive distributed lag (ARDL) framework, this study attempts to investigate the impact of total public debt on inflation ...
Akingbade U. Aimola +1 more
doaj +1 more source
Lower bounds for linear degeneracy testing [PDF]
Journal of the ACM, 2004 In the late nineties, Erickson proved a remarkable lower bound on the decision tree complexity of one of the central problems of computational geometry: given n numbers, do any r of them add up to 0? His lower bound of Ω( n ⌈ r
Nir Ailon, Bernard Chazelle
openaire +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Lower Bounds for Convexity Testing
We consider the problem of testing whether an unknown and arbitrary set $S \subseteq \mathbb{R}^n$ (given as a black-box membership oracle) is convex, versus $\varepsilon$-far from every convex set, under the standard Gaussian distribution. The current state-of-the-art testing algorithms for this problem make $2^{\tilde{O}(\sqrt{n})\cdot \mathrm{poly ...
Xi Chen 0001 +4 more
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source