Results 81 to 90 of about 884 (173)

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, Volume 13, Issue 8, Page 1628-1637, August 2026.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

IL‐6 Upregulates CD73 in Human Placental Mesenchymal Stem Cells to Promote ATRA‐Induced NB4 Cell Differentiation in Acute Promyelocytic Leukemia

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Purpose To investigate the expression profile of IL‐6 in patients with acute promyelocytic leukemia (APL) and its role in modulating the ability of hPMSCs to regulate the differentiation of NB4 cells. Methods Peripheral blood samples were obtained from newly diagnosed APL patients and healthy controls.
Rong Qi, Hengchao Zhang, Yunhua Wu, Yanchao Ma, Xiying Luan   +4 more
wiley   +1 more source

EFFECTIVENESS OF SEROLOGICAL TESTS FOR DIAGNOSTICS OF BOVINE EPHEMERAL FEVER

Ветеринария сегодня, 2018
Review of publications devoted to spread of bovine ephemeral fever (BEF) in the world is presented; epizootic aspect of this problem is highlighted. The disease is not registered in Americas, Island, New Zealand and Europe.
Ye. A. Konstantinova, S. K. Starov, A. V. Konstantinov, V. I. Diev, A. K. Karaulov   +4 more
doaj  

Mycoplasma Contamination Alters the Expression Profile of Pro‐Inflammatory Cytokines by Human Innate Immune Cells

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT The impact of Mycoplasma contaminations on in vitro test systems has been extensively discussed and in vitro studies have demonstrated various effects on the physiology of the contaminated cell line. Thus far, little is known about the effect of biologically active substances, such as viruses produced in contaminated cell lines on primary ...
Patricia Gogesch, Stefanie Kronhart, Marc A. Niles, Georg Kochs, Zoe Waibler, Martina Anzaghe   +5 more
wiley   +1 more source

SARS‐CoV‐2 Spike Peptides Trigger Nociceptive Responses Through Spinal TLR4 Pathways

European Journal of Pain, Volume 30, Issue 7, August 2026.
ABSTRACT Background Pain is a common neurological manifestation of COVID‐19, yet the mechanisms by which SARS‐CoV‐2 spike protein fragments contribute to nociceptive processing remain poorly understood. We investigated whether spike‐derived peptides directly activate spinal neuroimmune pathways involved in pain signalling.
Bruno Eduardo Silva, Rayner Ribeiro Cardoso, Lívia Maria Ribeiro Rosário, João Paulo Prado, Rafaela Silva dos Santos, Flávio Protasio Veras, Mylena de Souza, Eduardo Maffud Cilli, Danilo Olivier, Marco Antonio de Andrade Belo, Ives Charlie‐Silva, Ester Siqueira Caixeta, Angel Roberto Barchuk, Albená Nunes‐Silva, Thiago Roberto Lima Romero, Giovane Galdino   +15 more
wiley   +1 more source

Phillyrin Alleviates Memory Impairment in D‐Galactose‐Induced Aged Mice by Suppressing Hippocampal Neuroinflammation via the TLR4/NF‐κB Signaling Pathway

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Phillyrin (PHI), a dietary bioactive lignan isolated from Forsythia suspensa, alleviates D‐galactose‐induced cognitive impairment by suppressing the TLR4/NF‐κB signaling pathway. PHI inhibits TLR4‐mediated activation of NF‐κB, thereby reducing neuroinflammation and oxidative stress, preserving neuronal structure and synaptic plasticity, and ultimately ...
Xuemin Li, Liru Wang, Chenyang Li, Junfeng Huo, Shuqin Li, Linxiu Bian, Ying Zhang, Yongfei Bai, Jie Yao, Xinyuan Hao   +9 more
wiley   +1 more source

Antibody Responses in Pediatric Dengue Indicate Emergence and Co‐Circulation of DENV‐3 Genotypes I and III in Myanmar and Orthoflavivirus Cross‐Reactivity

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT Dengue virus (DENV) remains a major public health concern in Southeast Asia, disproportionately affecting children. In Myanmar, DENV‐3 Genotype III predominated before 2017, with Genotype I emerging thereafter. To assess the impact of this emergence on antibody responses, we analyzed paired acute and convalescent serum samples from 38 ...
Jean Claude Balingit, Khine Mya Nwe, Htin Lin, Wah Wah Aung, Ryosuke Suzuki, Yuki Takamatsu, Takeshi Urano, Aye Aye Khin, Kyaw Zin Thant, Hlaing Myat Thu, Mya Myat Ngwe Tun, Kouichi Morita   +11 more
wiley   +1 more source

Defining Composition–Cytokine Relationships Enables the Design of Lipid Nanoparticles with Programmed Immunogenicity

Small, Volume 22, Issue 45, 13 August 2026.
Lipid nanoparticle composition governs distinct cytokine programs through the interplay of ionizable and polyethylene glycol‐conjugated (PEGylated) lipids. In vitro profiling, design of experiments (DoE) modeling, and in vivo validation reveal how formulation can tune reactogenicity‐associated pathways, while transgene expression remains the strongest ...
Adam Alexander Walters, Belal I. Hanafy, Chuan‐En Lu, Sara Marelli, Alaa Zam, Kai Liu, Rachel E. Foreman, Ramesh Soundararajan, Philippe Collin, Lennart Lindfors, Alan Sabirsh, Mariarosa Mazza, Khuloud T. Al‐Jamal, Stephanie M. Bates, George Thom, Jan Rehwinkel, Alexander N Kapustin   +16 more
wiley   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, Volume 7, Issue 4, August 2026.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Biomimetic MCC950‐loaded cerium‐layered double hydroxide nanoparticles for targeted treatment of Type 1 diabetes in streptozotocin‐induced mice

British Journal of Pharmacology, Volume 183, Issue 16, Page 4919-4938, August 2026.
The CLMBM nanoparticle (NP) system demonstrates strong and targeted anti‐ROS, antiapoptotic and anti‐inflammatory properties within the pancreas, thereby inhibiting the onset and progression of type 1 diabetes. Background and Purpose The destruction of β‐cells in type 1 diabetes is driven by signalling cascades that ultimately lead to cell apoptosis ...
Huiwen Pang, Zhuo Chen, Youzhi Wu, Thanh‐Truc Nguyen, Jingjing Wang, David M. Klyne, Zhi Ping Xu, Chen Chen, Alan Rowan, Felicity Y. Han   +9 more
wiley   +1 more source