Results 181 to 190 of about 113,938 (312)

Senolytic Treatment With Dasatinib and Quercetin Reshapes Influenza‐Specific CD8 T Cell Responses During Infection in Aged, Vaccinated Mice

open access: yesAging Cell, Volume 25, Issue 1, January 2026.
Impaired vaccination responses leave older adults more vulnerable to severe influenza (flu) infections. Pretreatment with senolytic Dasatinib and Quercertin (D + Q) did not improve vaccine responses but altered some responses to sublethal flu challenge. Despite these changes, overall flu outcomes were not impacted.
Andreia N. Cadar   +10 more
wiley   +1 more source

STAT3 SH2 Domain Aspartic Acid 661 Mutations Activate Immune Gene Programs

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT The conserved aspartic acid residue D661 within the STAT3 SH2 domain is a recurrent mutational hotspot in hematologic malignancies, including T‐cell large granular lymphocytic leukaemia, myelodysplastic syndromes and acute lymphoblastic leukaemia. To define the functional consequences of distinct STAT3D661 variants, we integrated computational,
Hye Kyung Lee   +10 more
wiley   +1 more source

Chronic Hepatitis B Virus Infection Acquired Under Cytostatic Treatment in Childhood — Clinical, Virological and Immunological Long‐Term Follow‐Up

open access: yesJournal of Viral Hepatitis, Volume 33, Issue 1, January 2026.
ABSTRACT Oncology patients receiving cytostatic therapy used to be at high risk of HBV infection when HBV screening measures were less reliable. Infections acquired under these conditions often persist, like those acquired perinatally or during early infancy.
Thomas Baumgarten   +10 more
wiley   +1 more source

The Differential Effects of Immunosuppressants on Hepatitis E Virus Replication and the Triggered Inflammatory Responses in Macrophages

open access: yesJournal of Viral Hepatitis, Volume 33, Issue 1, January 2026.
ABSTRACT Organ transplant recipients are at high risk of developing chronic infection when exposed to hepatitis E virus (HEV), which can rapidly progress to liver fibrosis and cirrhosis. Macrophages play a key role in the response to the infection and disease progression.
Jiahua Zhou   +4 more
wiley   +1 more source

Seroprevalence and Molecular Analysis of Bovine Leukemia Virus in Kazakhstan. [PDF]

open access: yesViruses
Mamanova S   +14 more
europepmc   +1 more source

Innovative Chorioallantoic Membrane Model as Valuable Tool in Diagnostics and Testing of Domestic Animal Cancers

open access: yesTransboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
In recent years, particular attention has been paid to the possible connections, similarities, and potential uses of animals, especially pets (dogs and cats), in research on the causes, characteristics, and treatment of cancers occurring in pets and humans. One of the most promising experimental research models used to explore these issues is the avian
Anna Sczasny   +3 more
wiley   +1 more source

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