Results 101 to 110 of about 86,735 (271)

Preliminary Analysis of Vital Proteins of the Human Respiratory Syncytial Virus [PDF]

, 2010
Human Respiratory Syncytial Virus infects the vast majority of children under the age of two and reoccurs in adulthood. It is a serious global problem as severe infection and death can result in the very young or very old and in immunocompromised people.
BACHE, HELEN,CLARE
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Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Establishment of a multiplex qPCR assay for the detection of pathogens associated with bovine respiratory disease complex

Frontiers in Veterinary Science
IntroductionThe bovine respiratory disease complex poses a significant threat to the cattle industry, necessitating a multifaceted approach to address its occurrence. The syndrome is caused by various pathogens such as bovine respiratory syncytial virus (
Linghao Li, Linghao Li, Qifeng Jiang, Qifeng Jiang, Siying Li, Siying Li, Xin Li, Xin Li, Shenghe Sun, Shenghe Sun, Xiyi Wang, Chuangqi Sun, Chuangqi Sun, Kun Jia, Kun Jia, Shoujun Li, Shoujun Li   +16 more
doaj   +1 more source

Histophilus somni: AS an ETIOLOGIC AGENT of BOVINE RESPIRATORY DISEASE COMPLEX (BRDC)

, 2023
The bovine respiratory disease complex (BRDC) is one of the leading causes of morbidity and mortality in cattle related to pneumonia. Many of the bacterial agents found in BRDC are associated with other predisposed environmental variables, physiological stresses, or concomitant illnesses. Mannheimia haemolytica, Pasteurella multocida, Histophilus somni,
openaire   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

Indonesian Herb Extracts Inhibit the Replication of Bovine Respiratory Syncytial Virus: In Vitro Study

Hayati Journal of Biosciences
Bovine respiratory syncytial virus (BRSV) is highly prevalent in cattle. It is a major viral cause of bovine respiratory disease complex, which is associated with morbidity, mortality and substantial economic impact.
Bambang Pontjo Priosoeryanto, Putu Eka Sudaryatma, Nafrina Lanniari, Surachmi Setiyaningsih, Eva Harlina, Retno Wulansari, Rachmi Ridho, Riski Rostantinata, Putu Angga Wiradana, Tamaki Okabayashi   +9 more
doaj   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Serological Evidence of Influenza D Virus Circulation Among Cattle and Small Ruminants in France

Viruses, 2019
Influenza D virus (IDV) has first been identified in 2011 in the USA and was shown to mainly circulate in cattle. While IDV is associated with mild respiratory signs, its prevalence is still unknown.
Justine Oliva, Amit Eichenbaum, Jade Belin, Maria Gaudino, Jean Guillotin, Jean-Pierre Alzieu, Philippe Nicollet, Roland Brugidou, Eric Gueneau, Evelyne Michel, Gilles Meyer, Mariette F. Ducatez   +11 more
doaj   +1 more source

Bovine adenovirus prevalence and its role in bovine respiratory disease complex: A systematic review and meta-analysis

The Veterinary Journal
Bovine adenoviruses (BAdVs) are major contributors to the bovine respiratory disease complex (BRDC). A systematic review and meta-analysis were carried out to explore the epidemiology of BAdV across diverse cattle populations using different detection methods.
Gebremeskel Mamu Werid, Yassein M. Ibrahim, Gebrerufael Girmay, Farhid Hemmatzadeh, Darren Miller, Roy Kirkwood, Kiro Petrovski   +6 more
openaire   +2 more sources

The biochemical and molecular characterisation of respiratory mucins in TB

, 2006
Includes bibliographical references (leaves 96-112).The role of the dominant respiratory mucins (MUC5AC and MUC5B) and MUC2 has been investigated in chronic airway diseases as it is the mucin glycoprotein that confers upon mucus its biological ...
Govender, Ureshnie
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