Results 111 to 120 of about 172,055 (278)

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

A novel approach to probe host-pathogen interactions of bovine digital dermatitis, a model of a complex polymicrobial infection [PDF]

, 2016
Background: Polymicrobial infections represent a great challenge for the clarification of disease etiology and the development of comprehensive diagnostic or therapeutic tools, particularly for fastidious and difficult-to-cultivate bacteria. Using bovine
Boye, Mette, Jensen, Tim K., Klitgaard, Kirstine, Marcatili, Paolo, Nielsen, Martin W., Nielsen, Morten, Schafer Nielsen, Claus, Sicheritz Ponten, Thomas   +7 more
core   +7 more sources

The role of Histophilus somni in the bovine respiratory disease complex

, 2023
Histophilus somni, besides being firstly isolated as the cause of thromboembolic meningoencephalitis, is nowadays regarded worldwide as one of the primary bacterial causes of bovine respiratory disease (BRD), as well as of some reproductive and cardiovascular diseases in both beef and dairy cows, leading to health impairment, economic losses, and ...
Compiani Riccardo, Grossi Silvia, Sgoifo Rossi Carlo Angelo   +2 more
openaire   +1 more source

RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis

Advanced Science, EarlyView.
Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao, Chao Ren, Li‐Yu Zheng, Jing‐Yan Li, Wen‐Feng Wu, Yu‐Xuan Li, Li‐Xue Wang, Yu Duan, Lu Wang, Shuang‐Qing Liu, Peng‐Yi He, Peng‐Yue Zhao, Sen Tong, Zhi‐Xuan Li, Tuo Zhang, Meng‐Yao Wu, Shu‐Ting Wei, Ning Dong, Yao Wu, Hui Zhang, Xiao‐Mei Zhu, Zi‐Cheng Zhang, Guo‐Sheng Wu, Zhao‐Fan Xia, Xiao‐Hui Du, Hong‐Jun Kang, Zui Zou, Dao‐Lin Tang, Yong‐Ming Yao   +28 more
wiley   +1 more source

Recent Role of Microorganisms of the Mollicutes Class in the Etiology of Bovine Respiratory Disease

Pathogens
Bovine respiratory disease (BRD) inflicts significant losses in cattle farming worldwide and is caused by the co-occurrence of various infectious agents which is often compounded by environmental factors.
Katarzyna Dudek, Robin A. J. Nicholas
doaj   +1 more source

Circumventing antivector immunity: potential use of nonhuman adenoviral vectors [PDF]

, 2014
Adenoviruses are efficient gene delivery vectors based on their ability to transduce a wide variety of cell types and drive high-level transient transgene expression. While there have been advances in modifying human adenoviral (HAdV) vectors to increase
Beard C.W., Benkö M., Cauthen A.N., Crawford-Miksza L., Estrella Lopez-Gordo, Gall J., Gall J.G., Gattoni A., Ginsberg H.S., Haviv Y.S., Hofmann C., Iva I. Podgorski, Kajon A.E., Kanerva A., Kass-Eisler A., Kuriyama S., Mastrangeli A., Michou A.I., Nicholas Downes, Ramon Alemany, Rogozhin V.N., Roy S., Seiradake E., Shmarov M.M., Soudais C., Tutykhina I.L., Wang D.Y., Wohlfart C., Ying B., Zakhartchouk A.N., Zeng Q.   +30 more
core   +3 more sources

Conformable Microelectrode Arrays Integrated with a Scoop‐Shaped Slide‐Well for Dynamic Electrophysiological Profiling of Patient‐Derived Cardiac Organoids

Advanced Science, EarlyView.
A flexible, ultrathin multi‐channel microelectrode array (MEA) conformally integrated onto a curved slide‐well enables stable electrical interfacing with 3D cardiac organoids. The geometry‐guided self‐alignment allows simultaneous recording of extracellular field potentials and contractile motion from irregular, beating tissues.
Ye Seul Kim, Jeonghwa Jeong, Gyeonghwa Heo, Young Woo Kwon, Jeongha Lee, Yoon Ji Jeong, Gyu Tae Park, Seongdo Jeong, Ki Won Hwang, Murim Choi, Jinhong Shin, Suck Won Hong, Jae Ho Kim   +12 more
wiley   +1 more source

Establishment of a multiplex qPCR assay for the detection of pathogens associated with bovine respiratory disease complex

Frontiers in Veterinary Science
IntroductionThe bovine respiratory disease complex poses a significant threat to the cattle industry, necessitating a multifaceted approach to address its occurrence. The syndrome is caused by various pathogens such as bovine respiratory syncytial virus (
Linghao Li, Linghao Li, Qifeng Jiang, Qifeng Jiang, Siying Li, Siying Li, Xin Li, Xin Li, Shenghe Sun, Shenghe Sun, Xiyi Wang, Chuangqi Sun, Chuangqi Sun, Kun Jia, Kun Jia, Shoujun Li, Shoujun Li   +16 more
doaj   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Indonesian Herb Extracts Inhibit the Replication of Bovine Respiratory Syncytial Virus: In Vitro Study

Hayati Journal of Biosciences
Bovine respiratory syncytial virus (BRSV) is highly prevalent in cattle. It is a major viral cause of bovine respiratory disease complex, which is associated with morbidity, mortality and substantial economic impact.
Bambang Pontjo Priosoeryanto, Putu Eka Sudaryatma, Nafrina Lanniari, Surachmi Setiyaningsih, Eva Harlina, Retno Wulansari, Rachmi Ridho, Riski Rostantinata, Putu Angga Wiradana, Tamaki Okabayashi   +9 more
doaj   +1 more source