Results 91 to 100 of about 69,319 (240)
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Work, Energy, and Efficiency of a Recurve Bow
International Scholastic Journal of Science, 2023 The shooting of a recurve bow was varied in two ways, changing draw distance and string length, to determine the relationship between work done in drawing the bowstring and the resulting kinetic energy of the arrow.
Sedthasard Kasetcharoenkit +1 more
doaj
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
PaleoAnthropologyThe invention of long-range weaponry has been a pivotal technological change with significant implications for Palaeolithic subsistence strategies and is assumed to have been a crucial factor facilitating the spread of anatomically modern humans while ...
Justin Coppe, Veerle Rots
doaj +1 more source
, 2010 Black bow tie with 'bow' at one end. For evening 'dress' wear - from the The Betty Smithers Design Collection at Staffordshire University.
The Betty Smithers Design Collection at Staffordshire University +1 more
core
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
At Bow Valley College, we appreciate that learners lead busy lives. This is why we take a flexible approach to your education, one that is responsive to your needs and learning style.
Bow Valley College
core +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Creating a digital shell for Indigenous language and culture sharing
, 2016 While there are many community-based programs for learning Indigenous languages around the world, there appears to be a dearth of opportunities to study these at a university level.
Bow, Cathy, Cathy Bow (3346250)
core +1 more source