Results 21 to 30 of about 3,546 (197)
Autopolyploidization‐Induced Chromatin Remodeling Regulates Leaf Size Variation in Brassica rapa
Advanced Science, EarlyView.This study demonstrates that monoploid, diploid, and autotetraploid Brassica rapa lines derived from the same genome exhibit distinct leaf morphology. Ploidy changes remodel chromatin accessibility and histone modifications to regulate gene expression, while key transcription factors BrGRF13 and BrARF11 control leaf size and polarity, driving ...
Haoyuan Dong +17 more
wiley +1 more source
Advanced Science, EarlyView.This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu +6 more
wiley +1 more source
Advanced Science, EarlyView.Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen +12 more
wiley +1 more source
Some Effects of Wing Planform on Sonic Boom [PDF]
, 1973 A wind-tunnel investigation was conducted to determine the effect of wing planform on sonic boom at Mach numbers of 1.7, 2.0, and 2.7. The results of the investigation show that the wing leading-edge sweep is one of the primary planform variables ...
Hicks, R. M. +2 more
core +1 more source
The Microbiota Shapes Central Nervous System Myelination in Early Life
Advanced Science, EarlyView.Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch +13 more
wiley +1 more source
Advanced Science, EarlyView.Uncovering a new layer of translational control, this study reveals how TRMT6/TRMT61A‐mediated tRNA‐m1A methylation drives pro‐tumorigenic senescence in colorectal cancer. By selectively enhancing ARG2 translation, this epitranscriptomic axis triggers an NF‐κB‐dependent SASP.
Tuoyang Li +17 more
wiley +1 more source
Impact of Retro Rocket Plumes on Upper Stage Aerodynamics during Stage Separation [PDF]
, 2015 In this paper we report on an extensive investigation of the separation process of the first two stages of a carrier rocket corresponding to VEGA, which employs solid rocket motors.
Gülhan, Ali, Hohn, Oliver
core +1 more source
Livestock Tango: U.S. and Latin America Dance Together, but Who Will Lead?
Applied Economic Perspectives and Policy, EarlyView.ABSTRACT This study examines the competitiveness between Latin American and U.S. livestock and meat sectors. We employ a computable general equilibrium modeling framework to evaluate two scenarios: coordinated improvements in Latin American productivity, transport efficiency, and market access (Scenario I), and the minimum productivity gains required ...
Taís C. Menezes +2 more
wiley +1 more source
A comparison of penetration and damage caused by different types of arrowheads on loose and tight fit clothing [PDF]
, 2018 Bows and arrows are used more for recreation, sport and hunting in the Western world and tend not to be as popular a weapon as firearms or knives. Yet there are still injuries and fatalities caused by these low-velocity weapons due to their availability ...
Beattie, Eilidh +5 more
core +2 more sources
Foreign labor, peer‐networking and agricultural efficiency in the Italian dairy sector
Agribusiness, EarlyView.Abstract While the presence of immigrants in the agricultural sector is widely acknowledged, the empirical evidence on its economic consequences is lacking, especially from a microeconomic perspective. Using the Farm Accountancy Data Network panel data for Italian dairy farms in the period 2008–2018, the present study investigates the relationship ...
Federico Antonioli +2 more
wiley +1 more source