Results 51 to 60 of about 13,470,210 (237)

Chitosan Nanocarrier Entrapping Hydrophilic Drugs as Advanced Polymeric System for Dual Pharmaceutical and Cosmeceutical Application: A Comprehensive Analysis Using Box-Behnken Design

Polymers, 2021
The objective of the present research is to propose chitosan as a nanocarrier for caffeine—a commonly used drug in combating cellulite. Being a hydrophilic drug, caffeine suffers from insufficient topical penetration upon application on the skin ...
Sara A Abosabaa, A. ElMeshad, Mona G Arafa   +2 more
semanticscholar   +1 more source

Optimization of the experimental parameters of fluticasone propionate microparticles for pulmonary delivery using a box behenken design

Journal of Pharmacy and Bioallied Sciences, 2012
The objective of this study was to examine extensively the influences of formulation and process variables on the microparticles. The microparticles were generated by the spray-drying technique using polymer chitosan, mannitol along with L-leucine.
P V Patel, T G Soni, V T Thakkar, T R Gandhi   +3 more
doaj   +1 more source

Optimization Studies on Imatinib Mesylate Loaded Nanoliposomes Using Box-Behnken Design

Nano Biomedicine and Engineering, 2022
Nanoliposomes are bilayer phospholipid vesicles used to encapsulate and deliver therapeutic agents. The study was aimed to investigate the effects of critical variables on nanoliposomes characteristics.
Mandeep Dahiya, Rajendra Awasthi, Gaurav Gupta, Sachin Kumar Singh, Monica Gulati, Niraj Kumar Jha, Saurabh Kumar Jha, Ankur Sharma, Parteek Prasher, Krishnan Anand, Dinesh Kumar Chellappan, Kamal Dua, Harish Dureja   +12 more
doaj   +1 more source

Designing pulse laser surface modification of H13 steel using response surface method [PDF]

, 2011
This paper presents a design of experiment (DOE) for laser surface modification process of AISI H13 tool steel in achieving the maximum hardness and minimum surface roughness at a range of modified layer depth.
Aqida, S.N., Brabazon, Dermot, Naher, Sumsun   +2 more
core   +1 more source

Optimization of Reaction Conditions in the Production of Gadolinium Diethylenetriamine Pentaacetate-Folate [PDF]

, 2015
A previous study has performed the laboratory-scale synthesis and characterization of Gadolinium Diethylenetriaminepentaacetate-Folate. Some parameters associated with the synthesis have been defined.
Anggraeni, A., Fauzia, R. P., Gunawan, A. H., Mutalib, A.   +3 more
core  

Box–Behnken Design (BBD)-Based Optimization of Microwave-Assisted Extraction of Parthenolide from the Stems of Tarconanthus camphoratus and Cytotoxic Analysis

Molecules, 2021
Parthenolide, a strong cytotoxic compound found in different parts of Tarchonanthus camphoratus which motivated the authors to develop an optimized microwave-assisted extraction (MEA) method using Box–Behnken design (BBD) for efficient extraction of ...
P. Alam, N. Siddiqui, M. Rehman, A. Hussain, A. Akhtar, S. Mir, M. Alajmi   +6 more
semanticscholar   +1 more source

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, EarlyView.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, EarlyView.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source

Optimization of bioethanol production from simultaneous saccharification and fermentation of pineapple peels using Saccharomyces cerevisiae

Journal of Applied Sciences and Environmental Management, 2018
In this study, bioethanol production from the simultaneous saccharification and fermentation (SSF) of pineapple peels using cellulase and Saccharomyces cerevisiae was investigated. A three-factor Box-behnken design (BBD) and response surface methodology
O Oiwoh, B.V. Ayodele, N.A. Amenaghawon, C.O. Okieimen   +3 more
doaj   +3 more sources

Using Box–Behnken experimental design to optimize the degradation of Basic Blue 41 dye by Fenton reaction

, 2020
Degradation of a Basic Blue 41 dye using Fenton reagent was examined at laboratory scale in batch experiments using Box-Behnken statistical experiment design.
Kiflie, Zebene, Solomon, Desta, Van Hulle, Stijn   +2 more
core   +2 more sources