Results 41 to 50 of about 12,276 (186)

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, EarlyView.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source

Quality-by-design based fabrication of febuxostat-loaded nanoemulsion: Statistical optimization, characterizations, permeability, and bioavailability studies

Heliyon, 2023
The present work deals with QbD-based development of FEB-loaded nanoemulsion (FEB-NE) in order to enhance bioavailability and permeability. In the beginning, the risk assessment was performed on different experimental variables using the Ishikawa diagram
Vishal C. Gurumukhi, Vivek P. Sonawane, Ganesh G. Tapadiya, Sanjaykumar B. Bari, Sanjay J. Surana, Shailesh S. Chalikwar   +5 more
doaj   +1 more source

Autonomous AI‐Driven Design for Skin Product Formulations

Advanced Intelligent Discovery, EarlyView.
This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang, Yongrui Xiao, Chunlin Chen, Dimitrios Tsaoulidis, Kai Yang, Tao Chen   +5 more
wiley   +1 more source

Formulation and characterization of ketoprofen liquisolid compacts by Box-Behnken design

International Journal of Pharmaceutical Investigation, 2012
Liquisolid technique is used in delivery of lipophilic and poorly water soluble drugs through oral route. It involves dissolving water insoluble drugs in nonvolatile solvents and converting into acceptably flowing and compressible powders. The objective of the present work was to enhance the dissolution rate of ketoprofen using microcrystalline ...
Vittal, G Vijayaranga, Deveswaran, R, Bharath, S, Basavaraj, BV, Madhavan, V   +4 more
openaire   +3 more sources

Design Optimization of Soft Fabric Pneumatic Actuators

Advanced Intelligent Systems, EarlyView.
This study presents a systematic optimization framework for elongating and bending fabric‐based soft pneumatic actuators. After a preliminary design‐space reduction, the framework minimizes energy consumption under mechanical performance constraints by integrating validated finite element modeling with statistical surrogate models. Optimal designs were
Grigorios M. Chatziathanasiou, Konstantina Tsintzira, Panagiotis Polygerinos   +2 more
wiley   +1 more source

Optimization of the Poly(glycerol citraconate) Synthesis Using the Box–Behnken Design

ACS Omega, 2023
This work aimed to obtain poly(glycerol citraconate) (PGCitrn) for biomedical applications, analyze the obtained polyester by spectroscopic methods, and optimize its preparation. Polycondensation reactions of glycerol and citraconic anhydride were carried out. It was provided that the results in the reaction are oligomers of poly(glycerol citraconate).
Krzysztof Kolankowski, Julia Rżewska, Paweł Ruśkowski, Agnieszka Gadomska-Gajadhur   +3 more
openaire   +2 more sources

Sustainable levulinic acid production from inulin via hydrothermal conversion

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract This study investigates the hydrothermal conversion of inulin using potassium pyrosulfate to levulinic acid (LA). The Box–Behnken design approach was applied to optimize the conversion parameters and analyze the interactions influencing LA yield.
Gwi‐Taek Jeong
wiley   +1 more source

Optimization of Physical and Cultural Conditions of Fibrinolytic Enzyme from Bacillus altitudinis S-CSR 0020

Journal of Pure and Applied Microbiology, 2018
The main aim of this work was optimization of physical conditions as well as medium components for the maximum production of fibrinolytic enzyme. A fibrinolytic enzyme producing organism was isolated from soil and identified as Bacillus altitudinis ...
K.V. Smitha, B.V. Pradeep
doaj   +1 more source

Eudragit®‐engineered pH‐responsive probiotic microspheres with enhanced gastrointestinal resistance and prolonged storage stability for inflammatory bowel disease therapy

BMEMat, EarlyView.
This study reports the development of AMS@Eud core‐shell microspheres, combining calcium alginate and pH‐responsive Eudragit® L100, which exhibit exceptional gastrointestinal resistance and long‐term storage stability (only 5.28%–9.09% viability loss over 35 days at 4–25°C), and effectively alleviate inflammatory bowel disease via gut microbiota ...
Ming Teng, Xiaomin Luo, Peng Zhang, Chen Yang, Yuniel Ma, Xinhua Liu   +5 more
wiley   +1 more source

Optimization of bioethanol production from simultaneous saccharification and fermentation of pineapple peels using Saccharomyces cerevisiae

Journal of Applied Sciences and Environmental Management, 2018
In this study, bioethanol production from the simultaneous saccharification and fermentation (SSF) of pineapple peels using cellulase and Saccharomyces cerevisiae was investigated. A three-factor Box-behnken design (BBD) and response surface methodology
O Oiwoh, B.V. Ayodele, N.A. Amenaghawon, C.O. Okieimen   +3 more
doaj   +3 more sources